ChemInform Abstract: HETEROCYCLE STABILIZED CARBANIONS. TWO SERIES OF ANOMALOUS PRODUCTS FROM 1‐ALKYL‐4,6‐DIPHENYL‐2‐PYRIDONES

Katritzky, Alan R.; Arrowsmith, John; Grzeskowiak, Nicholas E.; Salgado, Hector J.; Bahari, Zakaria bin

doi:10.1002/chin.198215251

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2018

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“…Among them, many molecules contained the tert-butyl 4-formyl-3, 6-dihydrop yridine-1(2H)-carboxylate (9).The structures of these compounds were shown in Fig.1. For example, 3,5-bis(4-methylbenzoylmethyl)-1-acetyl -4piperidinone(1) [15],methyl 2-(4-benzoyl-1-benzyl-5-ethylpiperidin-3-yl) acetate [18].Among them, compound 5 can also be used to develop drugs for the treatment of depression and cerebral ischemia, and compound 3 is a potential analgesic.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H) -carboxylate

Zhang¹,

Ye²,

Xu³

et al. 2018

Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)

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Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate(9) is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate was established in this work. The target compound was synthesized from the commercially available piperidin-4-ylmethanol (5) through four steps including nucleophilic substitution reaction, oxidation reaction, halogenation reaction and elimination reaction. The structure of the target product was confirmed by 1 H NMR. In addition, the synthetic method was optimized. The total yield of the four steps was high up to 71.4%. 263

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Section: Introductionmentioning

confidence: 99%