Tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate(9) is an important intermediate for small molecule anticancer drugs. A rapid and high yield synthetic method for tert-butyl 4-formyl-3, 6-dihydropyridine-1(2H)-carboxylate was established in this work. The target compound was synthesized from the commercially available piperidin-4-ylmethanol (5) through four steps including nucleophilic substitution reaction, oxidation reaction, halogenation reaction and elimination reaction. The structure of the target product was confirmed by 1 H NMR. In addition, the synthetic method was optimized. The total yield of the four steps was high up to 71.4%.
263
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.