ChemInform Abstract: Harnessing C—H Borylation/Deborylation for Selective Deuteration, Synthesis of Boronate Esters, and Late Stage Functionalization.

Abstract

A convenient synthesis of mono‐borylated heterocycles can be achieved by C—H diborylation followed by regioselective mono‐deborylation with methanol in the presence of [Ir(OMe)(cod)]2 as catalyst.

Meta Selective C–H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

“…To demonstrate the synthetic utility, we showed that the borylated compound (2a) can be transformed to many useful synthons employing known transformations, such as hydroxylation, 17 fluorination, 49 chlorination, 50 bromination, 50 deuteration, 51 arylation, 21 benzylation, 52 and azidation followed by cycloaddition 53 (Chart 6).…”