Transition metal-catalysed direct borylation of hydrocarbons via C–H bond activation has received a remarkable level of attention as a popular reaction in the synthesis of organoboron compounds owing to their synthetic versatility.
An
electrostatically directed meta borylation of sterically biased
and unbiased substrates is described. The borylation follows an electrostatic
interaction between the partially positive and negative charges between
the ligand and substrate. With this strategy, it has been demonstrated
that a wide number of challenging substrates, especially 4-substituted
substrates, can selectively be borylated at the meta position. Moreover,
unsubstituted substrates also displayed excellent meta selectivity.
The reaction employs a bench-stable ligand and proceeds at a milder
temperature, precluding the need to synthesize a bulky and sophisticated
ligand/template.
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