ChemInform Abstract: Gastroprotective Flavonoid Constituents from Oroxylum indicum Vent.

Babu, T. Hari; Manjulatha, K.; Kumar, Gopinatha Suresh; Hymavathi, A.; Tiwari, Ashok Kumar; Purohit, Muraleedhar; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1002/chin.201021208

Cited by 8 publications

(11 citation statements)

References 1 publication

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“…Current treatment options for patients suffering from gastrointestinal ulceration include antacids, sucralfate, prostaglandins, muscarinic antagonists, histamine-2 receptor antagonists (H2-RAs), and in particular, proton pump inhibitors. However, it has been observed that long-term use of H2-RAs and proton pump inhibitors induces hyperplasia in enterochromaffin-like cells, which may lead to a recurrence of the ulcer disease and induction of gastric cancer (Babu et al 2010). In addition, some of these treatments may cause side effects like hypersensitivity, arrhythmia, impotence, gynecomastia, and hematopoietic disturbances (Lakshimi et al 2009) Therefore, there is a need to search for more effective and safer anti-gastric ulcer agents with less side effects.…”

Section: Introductionmentioning

confidence: 98%

Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

Santin

Lemos

Klein‐Júnior

et al. 2010

Naunyn-Schmied Arch Pharmacol

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Syzygium aromaticum, a medicinal plant commonly known as clove, is used to treat toothache, respiratory disorders, inflammation, and gastrointestinal disorders. From the flower buds of S. aromaticum, it is possible to obtain an essential oil comprised of a mixture of aliphatic and cyclic volatile terpenes and phenylpropanoids, being eugenol as the main component. The aims of this study were: (1) to extract the essential oil of the flower buds of S. aromaticum, (2) to identify and quantify the main component of the essential oil, and (3) to evaluate its antiulcer activity using different animal models. Assays were performed using the following protocols in rats: indomethacin-induced and ethanol/HCl-induced ulcer model. Both essential oils from S. aromaticum and eugenol displayed antiulcer activities in the rat models of indomethacin- and ethanol-induced ulcer. Studies focusing on the possible mechanisms of gastroprotection were also undertaken using the following experiments: evaluation of gastric secretion by the pylorus-ligated model, determination of mucus in gastric content, participation of nitric oxide (NO) and endogenous sulfhydryl in gastric protection. The results show that there was no significant effect on the volume of gastric juice and total acidity. However, the quantification of free gastric mucus showed that the clove oil and eugenol were capable of significantly enhancing mucus production. With regard to the NO and endogenous sulfhydryls, the results demonstrated that the gastroprotection induced by clove oil and eugenol are not related to the activities of the nitric oxide and endogenous sulfhydryls. No sign of toxicity was observed in the acute toxicity study. In conclusion, the results of this study show that essential oil of S. aromaticum, as well as its main component (eugenol), possesses antiulcer activity. The data suggest that the effectiveness of the essential oil and eugenol is based on its ability to stimulate the synthesis of mucus, an important gastroprotective factor. However, further pharmacological and toxicological investigations are required to enable its use for the treatment of gastric ulcer.

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Section: Introductionmentioning

confidence: 98%

Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

Santin

Lemos

Klein‐Júnior

et al. 2010

Naunyn-Schmied Arch Pharmacol

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“…It can act as an antioxidant and has been found to cause apoptosis in cancer cells [16]. Seeds, root bark and stem bark of this plant are reported to contain ellagic acid [4,17]. To evaluate the quantification of ellagic acid in in vivo and in vitro samples of O. indicum, a simple rapid and accurate RP-HPLC method was used.…”

Section: Resultsmentioning

confidence: 99%

HPLC Method for Quantification of Ellagic Acid in in Vivo and in Vitro Plant Parts of Oroxylum Indicum (L.) Vent.

Rami¹,

Rami²,

Patel³

2017

Asian J Pharm Clin Res

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Objective: This study was performed to investigate the comparative analysis of ellagic acid content in in vivo (stem, leaf, and root) and in vitro (callus, in vitro developed root and shoot) samples of Oroxylum indicum (L.) Vent. an important medicinal plant. Methods:For in vitro culture, seedling explants were inoculated on MS (Murashige and Skoog's, 1962) medium, supplemented with N6-benzylaminopurine (BAP) and Kn alone and combination with indole acetic acid (IAA). Analytical method high performance liquid chromatography (HPLC) was developed for the quantification of ellagic acid in in vivo and in vitro samples.Result: BAP combination with IAA was best for shoot multiplication, BAP with 2,4-D were used for callus proliferation. HPLC analysis of these extracts revealed that the quantity of ellagic acid present in both the samples, but maximum ellagic acid content was obtained in leaves among all plant parts. Conclusion:Hence, this study showed the in vivo as well as in vitro samples contain ellagic acid. That can be used for its large scale production in future.

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“…This is the first report identifying the DPPH free radical scavenging and rat intestinal a-glucosidase inhibitory activity for the benzyl-substituted flavones. All the new compounds were characterized by detailed spectroscopic analysis [10].…”

Section: Resultsmentioning

confidence: 99%

“…Fresh O. indicum roots were collected from the Manuguru forest, Andhra Pradesh and processed as per the literature method to obtain oroxylin A, baicalein, and chrysin [10].…”

Section: Extraction and Isolationmentioning

confidence: 99%

Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors

Kumar

Tiwari

Rao

et al. 2010

Journal of Asian Natural Products Research

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Pharmacologically motivated natural product investigations have yielded a large variety of structurally unique lead compounds with interesting biomedical properties, but the natural roles of these molecules often remain unknown. In the present investigation, a series of benzyl substituted-flavone derivatives have been synthesized from the lead compounds and were screened against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and α-glucosidase inhibitory properties. The resulting activity profiles of these flavone derivatives were compared for degree of similarity to the profile of 1-3. Most of the synthesized derivatives displayed potent activities when compared to the parent compounds. Maximum potencies for DPPH free radical scavenging activity were observed only in compounds containing the 4-hydroxyl substitution and 3-methoxyl group on the phenyl ring. While the 2- and 4-hydroxyl group substitutions on the phenyl ring seem to be crucial for the intestinal α-glucosidase inhibitory activity.

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ChemInform Abstract: Gastroprotective Flavonoid Constituents from Oroxylum indicum Vent.

Cited by 8 publications

References 1 publication

Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models

HPLC Method for Quantification of Ellagic Acid in in Vivo and in Vitro Plant Parts of Oroxylum Indicum (L.) Vent.

Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors

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