ChemInform Abstract: Design, Synthesis and Pharmacological Evaluation of 1,3,4‐Oxadiazole Derivatives of Aryl Acetic Acid as Antiinflammatory and Analgesic Agents.

Abstract

Two series of 1,3,4‐oxadiazole derivatives of type (III) and (VII) are prepared and tested as anti‐inflammatory and analgesic agents.

Untitled

“…Mohammad Amir et al, (2011), synthesized 2-[(5diphenylmethyl-1,3,4-oxadiazole-2-yl)sulfanyl]-N(substitutedphenyl)-acetamides 3a-e, newly synthesized compounds were investigated for their anti-inflammatory effect by carrageenan-induced paw edema model using wistar rats (180-200g), analgesic activities of the compounds were studied by tail immersion method using albino mice (25-30g). The compounds 3a, 3b, and 3c showed significant anti-inflammatory activity 3 .…”

Review on Substituted 1,3,4-Oxadiazole and Its Biological Activities

“…6 The stable oxadiazoles appear in a many pharmaceutical drugs which include raltegravir, fasiplon, butalamine, oxolamine, pleconaril 4 and Nesapidil. 7 Oxadiazole have occupied a unique place in the field of medicinal chemistry due to its wide range of activities like antimicrobial 8,3 , anti-inflammatory, 9,10 anti-fungal, 11 antitubercular 12,13 , anti-convulsant 14 , anthelmintic, herbicidal, antioxidant, analgesic, 15,16 anti-tumour 17,18,19 and anti-hepatitis B viral activities. 20…”

Synthesis and <i>in Vitro</i> Antitumor Activity of 1,3,4-Oxadiazole Derivatives Based on Benzisoselenazolone

“…It has been shown that 1,3,4-oxadiazole derivatives possess interesting biological properties such as anticancer, 8) antibacterial, 9) anti-inflammatory 10) and anticonvulsant activity.…”