ChemInform Abstract: Cyclophilic Reactions of Allene‐1,3‐dicarboxylic Esters. Part 5. New Preparations of Quinolones.

Doad, G. J. S.; Jordis, Ulrich; Rudolf, Matthias; Sauter, F.; Scheinmann, F.

doi:10.1002/chin.198715227

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“…The nitrogen-based substrates were commonly prepared by different strategies stoichiometrically by using palladium catalyst. [37] Torii and co-workers proposed a synthetic scheme for synthesizing indoxyl and quinolone by coupling 2-iodoani-lines and phenylacetylenes in the presence of palladium as a catalyst with good yields (Scheme 24). [38] These techniques generate amide-containing by-products or a mixture of cyclic and non-cyclic intermediate.…”

Section: Selective One-pot Synthesis Of Indoxyl and Quinolonementioning

confidence: 99%

A Comprehensive Account of Synthesis and Biological Activities of α‐lidene‐ Benzocycloalkanones and Benzoheterocycles

et al. 2022

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α-lidene-benzocycloalkanones or benzene-fused cycloalkanones are a significant moiety in medicinal chemistry. Drug development using these moieties can explore the pharmacophoric space owing to their sp 2 and sp 3 hybridization, highly flexible bicyclic structure, and varied ring diameters. In addition, it imparts a more significant contribution based on stereochemistry and pliability in the three-dimensional space. The α-lidene-benzocycloalkanone series is a challenging target as it has multiple reactive sites, such as the bicyclic benzoannulated center, the reactive carbonyl fragment, and the partly hydrogenated ring of varying sizes. This domain lacks discussion and organized material, and this review can fill that gap, focusing on medicinally essential moieties like tetralone, indanone, and suberine. In addition, this review discusses αlidene-benzoheterocycles that are promising in the field of drug development. Due to their stereogenecity and target selectivity, most research and applications focus on unstrained 5 and 6-membered rings, such as α-lidene-benzocyclopentanones, α-lidene-benzocyclohexanones, α-lidene-benzofurano-3-ones, α-lidene-benzopyrano-3-ones, and α-lidene-indolin-3ones. This review shall also aid medicinal chemists in determining the optimal technique for developing novel benzene fused heterocycles or carbocycles with various biological activities.[a] M.

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Section: Selective One-pot Synthesis Of Indoxyl and Quinolonementioning

confidence: 99%

A Comprehensive Account of Synthesis and Biological Activities of α‐lidene‐ Benzocycloalkanones and Benzoheterocycles

et al. 2022

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ChemInform Abstract: Cyclophilic Reactions of Allene‐1,3‐dicarboxylic Esters. Part 5. New Preparations of Quinolones.

Abstract: The esters (I) react with the allene (II) in the presence of a base to afford the title quinolones (III).

Cited by 1 publication

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A Comprehensive Account of Synthesis and Biological Activities of α‐lidene‐ Benzocycloalkanones and Benzoheterocycles

A Comprehensive Account of Synthesis and Biological Activities of α‐lidene‐ Benzocycloalkanones and Benzoheterocycles

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