ChemInform Abstract: Chemistry of Novel Compounds with Multifunctional Carbon Structure. Part 4. Steric and Electronic Influences on the Diastereoisomeric Chemical Shift Differences in 19F NMR Spectra by Introduction of Fluorine, Phenyl, and Heteroatom Groups into Acetates.

Abstract

In order to develop reagents which are more efficient than MTPA (α‐methoxy‐α‐trifluoromethylphenylacetic acid) for the determination of enantiomeric excess, several fluoroacetic esters such as (I) are prepared and the 1H and 19F chemical shift differences of their s‐butyl ester, α‐phenylethyl ester and α‐phenylethylamide diastereomeric pairs measured.