ChemInform Abstract: Biological Properties of Hydroxytyrosol and Its Derivatives

Fernandez‐Bolanos, J.; López, Óscar; López-García, María Ángeles; Marset, Azucena

doi:10.1002/chin.201329266

Cited by 6 publications

(9 citation statements)

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“…31 Thus, HT and its derivatives inhibit chain propagation by donating a hydrogen to the alkylperoxyl radicals formed in the initiation step, and the resulting phenoxy radical is stabilized by an intramolecular Hbond with the −OH group. 32 The application of the pseudophase kinetic model to determining AO distributions and interfacial AO concentrations has already been published elsewhere and is briefly described in the Supporting Information (section S1). The results obtained here with HT and its esters confirm the relationships between the AO efficiency and the percentage of AO in the interfacial region previously demonstrated for the gallic 11 and caffeic 10 acid ester series.…”

Section: ■ Introductionsupporting

confidence: 89%

Interfacial Concentrations of Hydroxytyrosol and Its Lipophilic Esters in Intact Olive Oil-in-Water Emulsions: Effects of Antioxidant Hydrophobicity, Surfactant Concentration, and the Oil-to-Water Ratio on the Oxidative Stability of the Emulsions

Almeida

Losada‐Barreiro

Costa

et al. 2016

J. Agric. Food Chem.

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We determined the interfacial molarities of the antioxidants, AOs, hydroxytyrosol (HT), and HT fatty acid esters with chain lengths of 1 to 16 carbons in intact olive oil/water/Tween 20 emulsions. The results were compared with chain length effects on the oxidative stability of the same emulsions, and a direct correlation was established. Both (AOI) molarities (varying 50-250 times greater than the stoichiometric 3.5 × 10(-3) M AO concentration) and antioxidant efficiencies show similar parabola-like dependences on AO chain length with a maximum at C8, consistent with the "cut-off" effect often observed at longer chain lengths. Results should aid in understanding the complex structure-reactivity relationships between AO efficiencies in emulsified systems and their hydrophobilic-hydrophobic balance.

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Section: ■ Introductionsupporting

confidence: 89%

Interfacial Concentrations of Hydroxytyrosol and Its Lipophilic Esters in Intact Olive Oil-in-Water Emulsions: Effects of Antioxidant Hydrophobicity, Surfactant Concentration, and the Oil-to-Water Ratio on the Oxidative Stability of the Emulsions

Almeida

Losada‐Barreiro

Costa

et al. 2016

J. Agric. Food Chem.

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“…The results were reported as mg AAE/g. The methodology outlined by Patel [65] and Ali et al [62] was slightly modified in order to determine the ferrous ion chelating activity using 562nm absorbance. Using this approach, 15μL of extract was combined with 50μL of ferrous chloride (2 mM), 85μL of water and 50μL of ferrozine (5mM), as well as the mixture was incubated at 25°C for 10 minutes.…”

Section: Antioxidant Potentialmentioning

confidence: 99%

Preparation of Ultrasound-Assisted Herbal Coffee Infusion, Bioaccessibility of Phenolic Compounds and Their Antioxidant, Anti-diabetic, and Anti-Alzheimer Potential

Ali

2024

Preprint

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Herbal Coffee is getting more popular due to its unique flavor and higher concentration of bioactive compounds, mainly polyphenols. Rosemary is a unique herb with potent antioxidant properties. A green technique called ultrasound aids in releasing bioactive substances from the plant cell wall. In this context, ultrasound-assisted herbal coffee prepared and their anti-diabetic, anti-Alzheimer, and antioxidant activities were measured while the LC/MS was used to determine the bioactive components from the herbal coffee infusion. A total of 95 secondary metabolites were putatively reported, including alkaloids, phenolic acids, and flavonoids, which we identified in the herbal coffee infusion. The total phenolic content (61.5 ± 5.1 mg GAE/g), total flavonoid content (19.3 ± 0.9 mg QE/g), and total condensed tannin (7.6 ± 0.7 mg CE/g) of herbal coffee infusion were observed to be highest of the two remaining samples. The herbal coffee extracts were used to determine all samples' antioxidant, anti-diabetic, and anti-Alzheimer activities. Using LC-MS/MS, we semi-quantified 19 phenolic metabolites. The results show numerous bioactive components in herbal coffee infusion with more potent antioxidant, antidiabetic, and anti-Alzheimer potential. Moreover, more studies must be conducted to confirm how the metabolomic profile of herbal coffee affects its flavor profile.

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“…In the past few years, a large number of HTyr-derived compounds have been synthesized, and several of them have been described in recent reviews. − In particular, many experiments have been performed to synthesize HTyr derivatives and analogues with a better hydrophilic/lipophilic balance (HLB) to increase their availability and to join HTyr to other biologically active compounds to enhance its biological functions. The biological activities of HTyr-derived compounds have been evaluated in cell-free and cell-based models, and, as reported by Manna et al, the results obtained from the use of the two different experimental models were not always comparable.…”

Section: Introductionmentioning

confidence: 99%

Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy

et al. 2015

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Hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] is a phenolic compound found in olive leaves and fruits and extra-virgin olive oil, which has well-known strong antioxidant and radical-scavenging properties. Recently, it has received particular attention for its antiproliferative and apoptotic activities and its anti-inflammatory properties. During the past few years, more efforts have been focused on synthesizing HTyr-derived compounds with enhanced biological activities for their potential use in different chronic degenerative diseases. In this paper, we report a dissertation on the current knowledge of selected synthetic HTyr derivatives and analogues and their potential use in cancer prevention and therapy, which are related to their antioxidant, antiproliferative/apoptotic, and anti-inflammatory properties. On the basis of the perspective of using HTyr-derived compounds as anticancer agents, we have taken into account only studies that were performed in experimental cell-based models.

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ChemInform Abstract: Biological Properties of Hydroxytyrosol and Its Derivatives

Abstract: Review: 93 refs.

Cited by 6 publications

References 0 publications

Interfacial Concentrations of Hydroxytyrosol and Its Lipophilic Esters in Intact Olive Oil-in-Water Emulsions: Effects of Antioxidant Hydrophobicity, Surfactant Concentration, and the Oil-to-Water Ratio on the Oxidative Stability of the Emulsions

Interfacial Concentrations of Hydroxytyrosol and Its Lipophilic Esters in Intact Olive Oil-in-Water Emulsions: Effects of Antioxidant Hydrophobicity, Surfactant Concentration, and the Oil-to-Water Ratio on the Oxidative Stability of the Emulsions

Preparation of Ultrasound-Assisted Herbal Coffee Infusion, Bioaccessibility of Phenolic Compounds and Their Antioxidant, Anti-diabetic, and Anti-Alzheimer Potential

Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy

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