ChemInform Abstract: Antitumor Polycyclic Acridines. Part 7. Synthesis and Biological Properties of DNA Affinic Tetra‐ and Pentacyclic Acridines.

Stanslas, Johnson; Hagan, Damien J.; Ellis, Mary; Turner, Claire; Carmichael, James; Ward, Wil O. C.; Hammonds, Timothy R.; Stevens, Malcolm F. G.

doi:10.1002/chin.200031159

Cited by 3 publications

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“…The length and width of tumors were measured and the volume (v) was calculated using the formula v = (width) 2 × (length/2). 14 …”

Section: In Vivo Antitumoral Assaymentioning

confidence: 99%

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Wahyuni¹,

Hui²,

Stanslas³

et al. 2017

JYP

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Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion:The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.

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“…The length and width of tumors were measured and the volume (v) was calculated using the formula v = (width) 2 × (length/2). 14 …”

Section: In Vivo Antitumoral Assaymentioning

confidence: 99%

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Wahyuni¹,

Hui²,

Stanslas³

et al. 2017

JYP

Self Cite

View full text Add to dashboard Cite

show abstract

“…The absorbance of the formazan solutions was determined at 550 nm using a microplate reader (VersaMax, Molecular Devices, Inc., Sunnyvale, CA, USA). The IC 50 values (concentration of drugs that will produce a 50% reduction in the absorbance compared with untreated controls) were determined from the dose-response curves (Stanslas et al, 2000).…”

Section: Cell Culturementioning

confidence: 99%

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

Jabit¹,

Wahyuni²,

Khalid³

et al. 2009

Pharmaceutical Biology

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Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives

Tseng

Chen

et al. 2008

Bioorganic & Medicinal Chemistry

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ChemInform Abstract: Antitumor Polycyclic Acridines. Part 7. Synthesis and Biological Properties of DNA Affinic Tetra‐ and Pentacyclic Acridines.

Cited by 3 publications

References 1 publication

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Cytotoxic and nitric oxide inhibitory activities of methanol extracts ofGarciniaspecies

Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives

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