ChemInform Abstract: ANALOGS OF THE HISTAMINE LIBERATING DIHYDROXYSESQUITERPENE LACTONE THAPSIGARGIN. SYNTHESIS, X‐RAY ANALYSIS AND CHEMISTRY

Abstract

Ausgehend von den γ‐Ketosäuren (I) lassen sich Racemate der anellierten Furane (V), (VII) und (VIII) auf den beschriebenen Synthesewegen darstellen.

Recent Advances in the Synthesis of Sesquiterpenolides from Umbelliferae

“…They are generically named as thapsigargins, after thapsigargin itself, the leading compound. The interest for these metabolites arose after the discovery of thapsigargin to be a potent histamine liberator [15][16][17][18]. Nevertheless, thapsigargin is mainly known by its capacity to inhibit selective and irreversibly the functioning of the enzymes involved in the transport of the cations Ca 2+ from the cell cytosol to the sarco-and endoplasmic reticulum which act as reservoir of these ions.…”