ChemInform Abstract: A One‐Pot Synthesis of 5,7‐Diaryl‐1,5‐dihydro(or 1,2,3,5‐tetrahydro)‐pyrano[2,3‐d]pyrimidin‐2,4‐diones(or 2‐thioxo‐4‐ones).

Ahmed, Monzur Morshed; Romman, Ukr; Akhter, Khaleda; Halim, Md. Abdul; Rahman, Md. Mahbubur; Ahmed, S.M. Zabed

doi:10.1002/chin.201145154

Cited by 3 publications

(3 citation statements)

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“…With this background, in continuation to our works (Ahmed et al, 2006, Ahmed et al, 2011, Ullah et al, 2012and Rahman et al, 2013 on the synthesis of barbituric acid and thio-barbituric acid derivatives, we report herein syntheses…”

Section: Introductionsupporting

confidence: 71%

One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I

Akhter

Ahmed

Halim

et al. 2016

Bangladesh J. Sci. Ind. Res.

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Some new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-h) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-h have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds 3a-h do not seem to be available in the literatureBangladesh J. Sci. Ind. Res. 51(2), 129-138, 2016

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Section: Introductionsupporting

confidence: 71%

One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I

Akhter

Ahmed

Halim

et al. 2016

Bangladesh J. Sci. Ind. Res.

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“…Having this background, in continuation of the reported works 10,11 on the synthesis of 5, 7-diaryl-1, 5-dihydropyrano [2,3-d]pyrimidin-2, 4-diones, we report herein syntheses of 5-(4-chloro-phenyl)-7-phenyl-1, 5-dihydropyrano [2, 3-d]pyrimidine-2, 4-dione 3a, 5-(4-chlorophenyl)-7-p-tolyl-1, 5-dihydro-pyrano [2, 3-d]pyrimidine-2,4-dione 3b, 5-(4-chloro-phenyl)-7-phenyl-2-thioxo-1, 2, 3, 5-tetrahydro-pyrano [2, 3-d]…”

Section: Introductionmentioning

confidence: 57%

A One Pot Synthesis of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-D] pyrimidin-2, 4-diones (or 2-thioxo-4-ones)

Rahman

Ahmed

Siddiki

et al. 2013

Dhaka Univ. J. Sci.

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A number of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)-pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-f) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-c), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-f have been determined by UV, IR, 1 H NMR, 13 C NMR, mass spectral data and elemental analyses.

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“…Where, for the reactions the conventional reaction time and microwave reaction time were taken to the same extent of completion. In the present work, the reactions were carried out by following a general procedure [11][12][13].…”

Section: Rate Enhancementsmentioning

confidence: 99%

Synthesis of Bioactive Barbituric Acid Derivatives using Microwave Irradiation Method

Khatun¹,

Al-Reza²,

Sattar³

2016

International Journal of Advanced Research in Chemical Science

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The research work was involved in rapid and efficient procedure for the attachment of barbituric acid with arylidene acetophenone under microwave irradiation (MWI) and conventional heating. The result showed that the time was reduced from the conventional 24 hours to 5-10 minutes. In conventional heating, the yield of the compounds 2a-2e were very poor (77-81%), but in MWI methods the yields were observed 96-98% which was comparatively too high. The structures of the compounds were characterized by FT-IR, 1 H-NMR spectral data. The antimicrobial and cytotoxic activities of the synthesized compounds were also investigated. All the tested bacteria revealed the zone of inhibition were 6-13 mm where sample concentration was 100 μg disc -1 . However, cytotoxic analysis, the mortality 49-95% were appeared when sample concentration were 0.78-25 (μg ml -1 ) and more than 50 μg ml -1 concentration showed 100% mortality. The presence of a reactive and unsaturated ketone function in synthesized compounds was found to be responsible for their potential antimicrobial and cytotoxic activity.

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ChemInform Abstract: A One‐Pot Synthesis of 5,7‐Diaryl‐1,5‐dihydro(or 1,2,3,5‐tetrahydro)‐pyrano[2,3‐d]pyrimidin‐2,4‐diones(or 2‐thioxo‐4‐ones).

Cited by 3 publications

References 0 publications

One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I

One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I

A One Pot Synthesis of 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-D] pyrimidin-2, 4-diones (or 2-thioxo-4-ones)

Synthesis of Bioactive Barbituric Acid Derivatives using Microwave Irradiation Method

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