5,7-Diphenyl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano[2,3-d]pyrimidine (4a) has been synthesized in single-step by the condensation of barbituric acid (1) with benzylideneacetophenone (2a) in glacial acetic acid in the presence of phosphorous pentoxide. Reaction of barbituric acid (1) with arylideneacetophenones (2b-d) which gave the corresponding adducts of 5-(1,3-diaryl-1-oxopropyl) pyrimidine (1H, 3H, 5H)-2,4,6-triones (3a-c) previously in 50 % aqueous ethanol which on further reflux in gl. acetic acid in the presence of phosphorous pentoxide also gave the corresponding pyranopyrimidines 5,7-diaryl-1,2,3,4-tetrahydro-2,4-dioxo-5H-pyrano [2,3- d]pyrimidines (4b-d). The structures of the compounds 4a-d were characterized by their UV, IR, 1H NMR and 13C NMR spectral data.
Bangladesh J. Sci. Ind. Res. 41(3-4), 119-128, 2006
A Convenient One-Pot Synthesis of Substituted and Unsubstituted 2,4-Diaryl-5-oxo-5,6,7,8-tetrahydro-2-chromenes -[via ZnCl 2catalyzed condensation of cyclohexanediones (I) with arylideneacetophenones (II) (8 examples)]. -(AHMED, M. G.; AHMED, S. A.; ROMMAN, U. K. R.; SULTANA, T.; HENA, M. A.; KIYOOKA, S.; Indian J. Chem., Sect. B: Org.
Seven arylideneacetophenones: 1-(4-chlorophenyl)-3-phenyl-2-propen-1-one (1a), 1-(4-nitrophenyl)-3-phenyl-2-propen-1-one (1b) , 1-(4-methoxyphenyl)-3-phenyl-2- propen-1-one (1c) , 1-(4-methylphenyl)-3-phenyl-2-propen-1-one (1d) , 1-(4- chlorophenyl)-3-(4-methoxyphenyl)-2-propen-1-one (1e) , 1-(4-methylphenyl)-3-(4- methoxyphenyl)-2-propen-1-one (1f) and 1,3-di(4-methoxyphenyl)-2-propen-1-one (1g) were synthesized from the corresponding substituted acetophenones and benzaldehydes in presence of sodium hydroxide in aqueous ethanol. The structures of the compounds 1a-g were confirmed by their UV, IR, 1H NMR, 13C NMR spectral data.
Bangladesh J. Sci. Ind. Res. 42(1), 45-52, 2007
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