ChemInform Abstract: A New and Efficient Procedure for Friedlaender Synthesis of Quinolines in Low Melting Tartaric Acid‐Urea Mixtures.

Deep Eutectic Solvents in Organic Synthesis

“…Another Heteroaromatic synthesis that has been reported in the same acidic DES is the Friedlaender synthesis of quinolones. [65] The combination of a ketone and an ortho-aminoacetophenone in TTA/DMU at 70 °C afforded the target quinolones in good yield. Again, acidsensitive functionality, such as the ketal in the reaction in Scheme 34, survives these reaction conditions, demonstrating their functional group tolerance.…”