ChemInform Abstract: A Multi‐Component Synthesis of Functionalized O,S‐Dialkyldithiocarbonates.

Patra, Gopal C.; Pal, Sutanuka; Bhunia, Sankar C.; Hazra, N. K.; Pal, S. C.

doi:10.1002/chin.201640060

Cited by 2 publications

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“…Pal and coworkers have reported a single pot reaction of alcohol, activated vinyl compound as Michael acceptor and carbon disulfide in the existence of a tertiary amine, which provides O,S-dialkyldithiocarbonate derivatives in good yields at room temperature, which are beneficial building blocks for organic synthesis (Scheme 47). [78] Remarkably, an excess amount of carbon disulfide was used to overwhelm the direct Michael addition of alcohol with the vinyl compound. A number of bases including dry triethyl amine, DMAP (4-dimeth- The key to success of this reaction is the use of DABCO as catalyst with primary and secondary alcohols.…”

Section: Dithiocarbamatementioning

confidence: 99%

Multicomponent Approaches Involving Carbon Disulfide

Morja¹,

Viradiya

Chikhalia

2023

Asian J Org Chem

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In present scenario, innovative carbon disulfide‐involving multicomponent protocols are extremely advantageous for practical and efficient construction of acyclic as well as heterocyclic building blocks. Carbon disulfide is well recognized synthetic component and has achieved the desirability of scientific community for the preparation of a variety of highly functionalized organic scaffolds. Carbon disulfide involving MCRs mostly advantage from other features such as bond‐forming efficiency, resource effectiveness, the use of easily obtainable starting compounds, and atom‐economy, which make these protocols useful environmentally benign alternatives, in care with the greener way in which organic chemistry is going on. In this review article, we have discussed the noteworthy topical advances in the promising region of carbon disulfide‐involving multicomponent reactions. It highlight the prospects and confronts, emphasizing the diverse approaches established previously.

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Section: Dithiocarbamatementioning

confidence: 99%

Multicomponent Approaches Involving Carbon Disulfide

Morja¹,

Viradiya

Chikhalia

2023

Asian J Org Chem

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“…Alkylation of thiols or their salts is a well-developed method for the preparation of thioether derivatives. 22,23 Furthermore, these compounds were successfully synthesized via a variety of one-pot multistep [24][25][26] and multicomponent 27,28 alkylation reactions.…”

Section: Introductionmentioning

confidence: 99%

Multicomponent Solvent-Free Synthesis, Antibacterial Evaluation and QSAR Study of 2-(Bis(benzylthio)methylene) malononitriles

Beyzaei

Baranipour

Aryan

et al. 2018

ACSi

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Multicomponent reaction of malononitrile, carbon disulphide and various benzyl halides was developed as an efficient strategy for the synthesis of 2-(bis(benzylthio)methylene)malononitrile derivatives via two different procedures: (a) in the presence of K 2 CO 3 as a base in acetonitrile and (b) under solvent-free conditions in the presence of triethylamine. Higher yields with shorter reaction times were obtained from the latter procedure. Inhibitory activity of all derivatives was evaluated against 22 pathogenic bacteria including both Gram-negative and Gram-positive strains. Thioether 4b showed broad-spectrum antibacterial activities according to the antibiogram tests. DFT calculations (B3LYP/6-311++G**) were performed to determine the type of drug-receptor interactions. It was found that reversible dipole-dipole forces play a key role in most interactions.

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ChemInform Abstract: A Multi‐Component Synthesis of Functionalized O,S‐Dialkyldithiocarbonates.

Cited by 2 publications

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Multicomponent Approaches Involving Carbon Disulfide

Multicomponent Approaches Involving Carbon Disulfide

Multicomponent Solvent-Free Synthesis, Antibacterial Evaluation and QSAR Study of 2-(Bis(benzylthio)methylene) malononitriles

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