ChemInform Abstract: 2‐Substituted‐3‐(4‐bromo‐2‐carboxyphenyl)‐5‐methyl‐4‐thiazolidinones as Potential Antiinflammatory Agents.

Goel, Bhawna; Ram, Tilak; Tyagi, Rajeev K.; Bansal, Ekta; Kumar, Ashok; Mukherjee, Devashish; Sinha, J. N.

doi:10.1002/chin.199934155

Cited by 3 publications

(3 citation statements)

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“…Compounds were screened and tested for their antimicrobial and antiinflammatory activities against E.coli, S.dysentriae and S.aures, C.albicans, R.oryzae by disc diffusion technique and carregeenan induced rat paw oedema method respectively. Structures of synthesized compounds were determined by spectral and chemical methods [36].…”

Section: Thiazolidinones As Antinflammatory Antiproteolytic and Antihemolytic Agentsmentioning

confidence: 99%

An Insight into 4-Thiazolidinones

Sahu

Upadhyay

Mishra

2021

JPRI

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Aims: This assessment is all about to get imminent into 4-thiazolidinones and comprehensively reviewing this molecule. 4-Thiazolidinones are known for their wide-ranging biological activities. 4 - Thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. The chemistry of thiazolidinones has drawn scientiﬁc interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti- inflammatory, anti-parasitic, hypnotic and anti-cancer. Structural modiﬁcations on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating different groups and moieties (A&B) on –CH– group of nucleus paving a new pathway for the future research. It necessitates to widely reviewing the structure, chemistry and pharmacological aspects of 4-thiazolidinones.

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Section: Thiazolidinones As Antinflammatory Antiproteolytic and Antihemolytic Agentsmentioning

confidence: 99%

An Insight into 4-Thiazolidinones

Sahu

Upadhyay

Mishra

2021

JPRI

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“…Pteropodine and isopteropodine, which are heteroyohimbine type oxindole alkaloids, act as positive modulators of muscarinic M (1) and 5-HT (2) receptors [12][13][14][15][16] . Azetidinone and thiazolidinone derivatives have been reported to possess antibacterial, antifungal 17,18 , antituberculor activity 19 , anti-HIV 20 analgesic, antiinflammatory 21 and ulcerogenic activity 22 . As well as spiroindolines, triazole derivatives have shown strong biological activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

Kandile

Mohamed

Ismaeel

2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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New compounds based on the indole moiety were synthesized via the reaction of indole-3-carbinal 1 with different nucleophiles such as 6-aryl-[4-(2-methoxybenzyl)pyridazin-3-yl] hydrazones 2a-c, benzidine, 3,3 0 -dimethoxybenzidine 4a,b and 2,6-diaminopyridine 6 to afford hydrazine derivatives 3a-c and three different classes of bis-Schiff bases. The structures of the new compounds were elucidated on the basis of their FTIR, 1 H NMR, 13C NMR spectral data, GC/MS and elemental analysis. The antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four pathogenic bacteria and two pathogenic fungi strains. Compound 14b showed excellent activity against Escherichia coli and Klebsiella pneumoniae. Some of the prepared compounds were tested for anti-cancer activity against human cell lines HCT116 (colon), MCF7 (breast) and HELA (cervix). From the results of the in vitro assays, compounds 3a,b, and 18a,c presented promising anti-cancer activity.

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“…4-Thiazolidinones have been synthesized for a wide range of pharmaceutical and biological purposes, including antibacterial [1], antifungal [2], anticonvulsant [3], antituberculous [4], antiinflammatory [5], antihistaminic [6] and antidepressant [7] properties. The discovery of antihelmintic properties of levamisole ((−)-2,3,5,6 -tetrahydro -6 -phenylimidazo [2,1 -b] thiazole) provoked a great deal of research on imidazo [2,1-b]thiazole derivatives [8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some New 6-Methylimid azo [2,1-b] thiazole-5-carbohydrazide Derivatives and their Antimicrobial Activities

Cesur

Birteksöz

et al. 2011

Arzneimittelforschung

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In this study, 14 new compounds having 6-methyl-N2-(alkylidene/cycloalkylidene)imidazo[2,1-b]thiazole-5-carbohydrazide (3a-g), 3-[[(6-methylimidazo[2,1-b]thiazole-5-yl)carbonyl]amino]-4-thiazolidinone (4a-d) and 4-[[(6-methylimidazo[2,1-b]thiazole-5-yl)carbonyl]amino]-1-thia-4-azaspiro[4.4]nonan/[4.5]decan-3-one (4e-g) structures were synthesized. The structures of the compounds were elucidated by UV, IR, 1H-NMR, 13C-NMR, 1H-13C-COSY, mass spectra and elemental analysis. All compounds synthesized were tested for antimicrobial activity against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis ATCC 14153, Candida albicans ATCC 10231 and Mycobacterium tuberculosis H37Rv. Only 4d and 4f demonstrated antimicrobial activity against S. epidermidis ATCC 12228 (MIC: 19.5 microg/ml and 39 microg/ml, respectively).

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ChemInform Abstract: 2‐Substituted‐3‐(4‐bromo‐2‐carboxyphenyl)‐5‐methyl‐4‐thiazolidinones as Potential Antiinflammatory Agents.

Cited by 3 publications

References 1 publication

An Insight into 4-Thiazolidinones

An Insight into 4-Thiazolidinones

Synthesis andin vitrobiological evaluation of new heterocycles based on the indole moiety

Synthesis of Some New 6-Methylimid azo [2,1-b] thiazole-5-carbohydrazide Derivatives and their Antimicrobial Activities

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