An Insight into 4-Thiazolidinones

Abstract

Aims: This assessment is all about to get imminent into 4-thiazolidinones and comprehensively reviewing this molecule. 4-Thiazolidinones are known for their wide-ranging biological activities. 4 - Thiazolidinones contains thiazolidine ring having carbonyl group in the 4-position. The chemistry of thiazolidinones has drawn scientific interest through the years because this particular ring system is the core structure in a variety of synthetic compounds with a broad spectrum of biological activities such as anti-bacterial, anti-fungal, insecticidal, anti-epileptic, anti-mycobacterial, anti- inflammatory, anti-parasitic, hypnotic and anti-cancer. Structural modifications on the 4-thiazolidinone moiety, either by replacing the aryl group with the heteroaryl scaffold or by incorporating different groups and moieties (A&B) on –CH– group of nucleus paving a new pathway for the future research. It necessitates to widely reviewing the structure, chemistry and pharmacological aspects of 4-thiazolidinones.

Proton tautomerism in 5-dimethylaminomethylidene-4-(o-,m-,p-hydroxyphenyl)amino-1,3-thiazol-2(5H)-ones: synthesis, crystal structure and spectroscopic studies

“…Molecules bearing this scaffold are known to have a remarkable range of biological activities, such as anticancer (Rashid et al, 2020;Szychowski et al, 2019), antibacterial (Tratrat et al, 2022), antitrypanosomal (Kryshchyshyn et al, 2019), anticonvulsant (Mishchenko et al, 2020), and many other. The continuing interest in constructing thiazolidinone-based hit compounds for drug design has been highlighted in several reviews (Lesyk, 2020a,b;Nirwan et al, 2019;Sahu et al, 2021). It is of note that the vast majority of the above-mentioned active compounds possess a double bond at position C5 of the heterocycle, which increases the biological activity and serves as a tool for chemical diversification (Kaminskyy et al, 2017).…”