Chemiluminescence response of whole blood and separated blood cells in cases of experimentally induced pancreatitis and MDTQ-DA—Trasylol—ascorbic acid therapy

Zimmermann, Thomas; Schuster, R.; Lauschke, G; Trausch, M.; Albrecht, Steffen; Kopprasch, Steffi; Kuehne, H.

doi:10.1016/0003-2670(91)80071-z

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…For the whole-blood superoxide production measurements, the chemiluminometric method of Zimmermann et al [21 ]was used. During the measurements, 10 μl of whole blood was added to 1 ml of Hank's solution and the mixture was kept at 37°C until assay.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory Activation after Experimental Cardiac Tamponade

Vass¹,

Süveges²,

Érces

et al. 2013

Eur Surg Res

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Background/Purpose: Cardiac tamponade is a medical emergency situation associated with a high rate of life-threatening complications, even after immediate interventions. Our aim was to characterize the acute inflammatory consequences of this event in a clinically relevant large animal model. Methods: Cardiac tamponade was induced for 60 min in anesthetized, ventilated and thoracotomized minipigs by intrapericardial fluid administration, the mean arterial pressure (MAP) being maintained in the interval of 40-45 mm Hg (n = 8). A further group (n = 7) served as sham-operated control. The global macrohemodynamics, including the right- and left-heart end-diastolic volumes (RHEDV and LHEDV), the pulmonary vascular resistance index (PVRI) and the superior mesenteric artery (SMA) flow, were monitored for 240 min, and the intestinal microcirculatory changes (pCO₂ gap) were evaluated by indirect tonometry. Blood samples were taken for the determination of cardiac troponin T and vasoactive inflammatory mediators, including histamine, nitrite/nitrate, big-endothelin, superoxide and high-mobility group box protein-1 levels in association with intestinal leukocyte and complement activation. Results: The cardiac tamponade induced significant decreases in MAP, cardiac output, LHEDV and SMA flow, while the PVRI and the pCO₂ gap increased significantly. After the removal of fluid from the pericardial sac, the MAP and the LHEDV were decreased, while the PVRI and the pCO₂ gap remained elevated when compared with those in the sham-operated group. In the posttamponade period, the abrupt release of inflammatory mediators was accompanied by a significant splanchnic leukocyte accumulation and complement activation. Conclusions: The macrocirculatory and splanchnic microcirculatory disturbances were accompanied by a significant proinflammatory reaction; endothelin and the complement system may be significant components of the inflammatory cascade that is activated in this porcine model of pericardial tamponade.

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Section: Methodsmentioning

confidence: 99%

Inflammatory Activation after Experimental Cardiac Tamponade

Vass¹,

Süveges²,

Érces

et al. 2013

Eur Surg Res

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“…The determination of plasma oxalate was performed chemiluminometrically as previously described (Albrecht et al, 1993;1994 The determination of H 2 O 2 /O À 2 was taken chemiluminometrically using luminol und lucigenin as sensitizers, as previously described (Zimmermann et al, 1991).…”

Section: Determination Of Oxalatementioning

confidence: 99%

Chemiluminometric measurement of NO and 77Se-NMR studies about the redox-sensitive behaviour of sodium selenite in the presence of peroxynitrite and H2O2/O2

Albrecht

Zimmermann

Scheller

et al. 1999

Biomed. Chromatogr.

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“…For the whole blood superoxide production measurements, the chemiluminometric method of Zimmermann et al (67) was used. During the measurements, 10 μL of whole blood was added to 1-mL Hank's solution (PAA Cell Culture, Westborough, MA) and the mixture was kept at 37°C until assay.…”

Section: Whole Blood Superoxide Productionmentioning

confidence: 99%

Influencing the macro- and microcirculatory complications of nonocclusive mesenteric ischemia by complement C5a inhibitor treatments

Nógrády¹

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Chemiluminescence response of whole blood and separated blood cells in cases of experimentally induced pancreatitis and MDTQ-DA—Trasylol—ascorbic acid therapy

Cited by 11 publications

References 6 publications

Inflammatory Activation after Experimental Cardiac Tamponade

Inflammatory Activation after Experimental Cardiac Tamponade

Chemiluminometric measurement of NO and 77Se-NMR studies about the redox-sensitive behaviour of sodium selenite in the presence of peroxynitrite and H2O2/O2

Influencing the macro- and microcirculatory complications of nonocclusive mesenteric ischemia by complement C5a inhibitor treatments

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