“…From a prevention standpoint, artichoke may improve the antioxidative defense system in healthy condition and may protect low‐density lipoprotein‐cholesterol from oxidation (Brown & Rice‐Evans, ; Goñi et al, ; Jiménez‐Escrig et al, ; Rezazadeh, Rahmati‐Yamchi, et al, ; Skarpanska‐Stejnborn et al, ). Moreover, in a treatment perspective, artichoke extracts could inhibit oxidative stress when animals are exposed to toxins and when human or animal cells are stimulated by agents that generate reactive oxygen species (Abdel‐Kader et al, ; Al‐Ahdab, ; Ben Salem & Affes, ; Brown & Rice‐Evans, ; Colak et al, ; El Morsy & Kamel, ; El‐Boshy et al, ; Gebhardt, ; Gebhardt & Fausel, ; Heidarian & Rafieian‐Kopaei, ; Jaleel et al, ; Juzyszyn et al, ; Kaymaz et al, ; Khattab et al, ; Löhr et al, ; Mehmetcik et al, ; Miccadei et al, ; Miláčková et al, ; Najim et al, ; Perez‐Garcia et al, ; Rahimuddin et al, ; Zapolska‐Downar et al, ). In addition, artichoke head extract exhibited apoptosis and chemopreventive properties in breast cancer cells and hepatoma cells by increased ROS production (Mileo et al, ; Mileo, Di Venere, Linsalata, Fraioli, & Miccadei, ).…”