Chemically Prepared Magnetic Nanoparticles

Willard, M. A.; Kurihara, Lynn K.; Carpenter, Everett E.; Calvin, S.; Harris, Vincent G.

doi:10.1002/chin.200535320

Cited by 24 publications

(32 citation statements)

References 1 publication

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“…These findings were all comparable to those of the commercial products obtained from Chemicell® (94 emu/g Fe) (15). Saturation magnetization was slightly lower than that of the bulk magnetite (127 emu/g Fe), probably due to the fact that the surface nonmagnetic layer (also known as "dead layer") of GA-MNP accounted for a higher composition fraction when the magnetite crystal size was reduced to nanosize (18). On the other hand, the saturation magnetization of GA-MNP was greater than that of the FDA-approved contrast agent Feridex® (70 emu/g Fe), possibly attributed to the smaller magnetite crystal size of Feridex® (∼4.8 nm) (19).…”

Section: Ga-mnp Characterizationsupporting

confidence: 79%

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Zhang

Cole

et al. 2009

AAPS J

115

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Magnetic iron oxide nanoparticles (MNP) coated with gum arabic (GA), a biocompatible phytochemical glycoprotein widely used in the food industry, were successfully synthesized and characterized. GA-coated MNP (GA-MNP) displayed a narrow hydrodynamic particle size distribution averaging about 100 nm; a GA content of 15.6% by dry weight; a saturation magnetization of 93.1 emu/g Fe; and a superparamagnetic behavior essential for most magnetic-mediated applications. The GA coating offers two major benefits: it both enhances colloidal stability and provides reactive functional groups suitable for coupling of bioactive compounds. In vitro results showed that GA-MNP possessed a superior stability upon storage in aqueous media when compared to commercial MNP products currently used in magnetic resonance imaging (MRI). In addition, significant cellular uptake of GA-MNP was evaluated in 9L glioma cells by electron spin resonance (ESR) spectroscopy, fluorescence microscopy, and MRI analyses. Based on these findings, it was hypothesized that GA-MNP might be utilized as a MRI-visible drug carrier in achieving both magnetic tumor targeting and intracellular drug delivery. Indeed, preliminary in vivo investigations validate this clinical potential. MRI visually confirmed the accumulation of GA-MNP at the tumor site following intravenous administration to rats harboring 9L glioma tumors under the application of an external magnetic field. ESR spectroscopy quantitatively revealed a 12-fold increase in GA-MNP accumulation in excised tumors when compared to contralateral normal brain. Overall, the results presented show promise that GA-MNP could potentially be employed to achieve simultaneous tumor imaging and targeted intra-tumoral drug delivery.

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Section: Ga-mnp Characterizationsupporting

confidence: 79%

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Zhang

Cole

et al. 2009

AAPS J

115

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“…Nanotechnology is playing an important role in providing effective solutions to the diverse environmental challenges [2]. Nanoparticles are particles between 1 and 100 nanometers (nm) in size with a surrounding interfacial layer [3]. Due to their size, nanoparticles demonstrate unique and controllable properties that are different from the macroscopic scale [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silica-Coated Fe₃O₄ Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity

Asab

Zereffa

Seghne

2020

International Journal of Biomaterials

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Magnetite and silica-coated magnetite (Fe3O4) nanoparticles (NPs) were synthesized by water-in-oil (W/O) microemulsion method from hydrated ferric nitrate, ferrous sulfate precursors and ammonia a precipitating agent with the assistance of Tween-80 and SDS surfactants. The synthesized materials were characterized by X-ray diffraction, scanning electron microscopy, thermal analyzer, and infrared spectroscopy. X-ray diffraction pattern of Fe3O4 showed that particles were phase pure with a cubic inverse spinel structure and FT-infrared spectra confirmed the presence of Fe-O bond in tetrahedral and octahedral interstitial sites. The crystallite size determined from powder XRD data with Scherer’s equation was in the range of 7.3 ± 0.05 nm–10.83 ± 0.02 nm for uncoated Fe3O4 and 16 ± 0.14 nm for silica-coated Fe3O4 NPs. The SEM micrographs of the uncoated Fe3O4 oxide revealed the agglomeration of the magnetite (Fe3O4) particles. But the silica-coated Fe3O4 oxide exhibited homogeneous distribution of particles with relatively less agglomerate of the particles. The particle size of Fe3O4 NPs slightly increased with the temperature and precursor concentration. The antimicrobial activities of Fe3O4 and silica-coated Fe3O4 nanoparticles were tested against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria. Both Fe3O4 and silica-coated Fe3O4 NPs demonstrated better antimicrobial activities.

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“…These authors believed that nano-particles, when loaded with chemotherapeutic agents, "may be favorably biased by size, and through the attachment of targeting ligands to the surface of the particle" would be capable of delivering drugs to cancerous tissues in preference to healthy tissues. Other researchers have shared this optimistic view over the past unsuccessful years of this drug-targeting development [e.g., Willard et al, 2004;Farokhzad and Langer, 2009] and offered [Yih and Al-Fandi, 2006] an even more naïve vision of nanoparticles, suggesting that these "colloidal structures with a diameter smaller than 1000 nm . .…”

Section: Discussionmentioning

confidence: 99%

Targeted Drug Delivery––Quo Vadis?

Petrak

2012

Drug Development Research

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Strategy, Management and Health Policy Enabling Technology, Genomics, ProteomicsPreclinical ResearchPreclinical Development Toxicology, Formulation Drug Delivery, PharmacokineticsClinical Development Phases I‐III Regulatory, Quality, ManufacturingPostmarketing Phase IV While business predictions suggest that 19 companies will have new or improved targeted drug delivery products on the market by 2018, no effective drug‐targeting systems have as yet been developed for use as human therapeutics despite a steadily increasing number of publications on the topic of drug targeting. This critical review argued that efforts in this field have failed so far largely because the basic requirements of targeted drug delivery are not been taken into consideration by researchers. The review outlines a systematic approach that should be adopted starting with determining whether the drug under consideration could benefit from site‐selective targeting based on its pharmacokinetic and pharmacodynamic behavior and on the physiological properties of the intended target site. A drug delivery system should advance to in vivo toxicity and efficacy testing only after it has been shown that it imparts to the drug the required pharmacokinetic properties.

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Chemically Prepared Magnetic Nanoparticles

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 24 publications

References 1 publication

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Synthesis of Silica-Coated Fe₃O₄ Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity

Targeted Drug Delivery––Quo Vadis?

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Chemically Prepared Magnetic Nanoparticles

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 24 publications

References 1 publication

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Synthesis of Silica-Coated Fe3O4 Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity

Targeted Drug Delivery––Quo Vadis?

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Product

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Synthesis of Silica-Coated Fe₃O₄ Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity