Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Zhang, Lei; Yu, Faquan; Cole, Adam; Chertok, Beata; David, Allan E.; Wang, Jingkang; Yang, Victor C.

doi:10.1208/s12248-009-9151-y

Cited by 116 publications

(65 citation statements)

References 25 publications

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“…[124] GA-coated magnetic NPs are used in simultaneous magnetic targeting and tumor imaging. [125] Magnetic iron oxide NPs (MNP) coated with GA, a biocompatible phytochemical glycoprotein widely used in the food industry. GA-coated MNP (GA-MNP) displayed a narrow hydrodynamic particle size, i.e., about 100 nm; a GA content of 15.6% by dry weight; a saturation magnetization of 93.1 EMU/g Fe; and a superparamagnetic behavior essential for most magnetic-mediated applications.…”

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

“…These GA-MNP NPs could potentially be employed to achieve simultaneous tumor imaging and targeted intra-tumoral drug delivery. [125] However, for sitespecific delivery of 5-fluorouracil to the colon GG acts as a carrier. Intravenous administration of 5-fluorouracil for colon cancer therapy produces severe systemic side-effects due to its cytotoxic effect on normal cells.…”

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

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Upadhyay

2017

IJGP

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The present review explains nutritional, therapeutic, and pharmaceutical potential of plant gum that is commonly applied to water-soluble, non-starch polysaccharides of commerce. This article also emphasizes commercial and domestic uses of important products of gum such as chicle and jelutong mainly non-elastic gums or chewing gums. These are also used in food, pharmaceutical, paper textile, and other industries. The present review also explains various biological activities such as antidiarrheic, antitumor, anti-inflammatory, anti-arthritic, antiparasitic, gastrourinary, antitumor, antiparasitic, antioxidant, chemopreventive, and gastroprotective activity of plant gums. These reduce stomach inflammation, system cleansing or to settle the intestines. Other uses for mesquite gum include treatment for lice, sore throat, cough, laryngitis, fever reduction, painful gums, and hemorrhoids and it can be used as a purgative. Gum arabic is a water-soluble dietary fiber rich in Ca , and decreases plasma phosphate concentration as well as urinary excretion of phosphate and Na + . Gums are used as adhesives, crystallization inhibitors, emulsifying agents, emulsion stabilizers, encapsulating agents, film formers, foam stabilizers, suspending agents, suspension stabilizers, or syneresis inhibitors and impart other specific properties. The gum is also used to a limited extent in polishes, contact insecticides and pesticides, photographic emulsions, and pharmaceuticals. This article suggests wider use of plant gums in generation of drug delivery system for cancer and brain tumor therapy. There is no doubt that chemical constituents of plant gums can be largely used for making therapeutic drugs because of their broadspectrum biological effectiveness.

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Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

Section: Use Of Gum In Development Of Drug Deliverymentioning

confidence: 99%

Untitled

Upadhyay

2017

IJGP

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“…[21][22][23] Among them, polysaccharides are the most widely studied coating materials for magnetite. [24][25][26] However, the potential of in vivo coating disassociation and bare magnetic particle exposure causing cellular toxicity are of significant concern. 27 Another limitation of current coating materials for magnetite is the complicated conjugation strategies or limited appreciated functional groups for specific ligand decoration on magnetite.…”

Section: Et Almentioning

confidence: 99%

Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy

Li¹,

Gendelman²,

Zhang³

et al. 2015

IJN

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Regimen adherence, systemic toxicities, and limited drug penetrance to viral reservoirs are obstacles limiting the effectiveness of antiretroviral therapy (ART). Our laboratory’s development of the monocyte-macrophage-targeted long-acting nanoformulated ART (nanoART) carriage provides a novel opportunity to simplify drug-dosing regimens. Progress has nonetheless been slowed by cumbersome, but required, pharmacokinetic (PK), pharmacodynamics, and biodistribution testing. To this end, we developed a small magnetite ART (SMART) nanoparticle platform to assess antiretroviral drug tissue biodistribution and PK using magnetic resonance imaging (MRI) scans. Herein, we have taken this technique a significant step further by determining nanoART PK with folic acid (FA) decorated magnetite (ultrasmall superparamagnetic iron oxide [USPIO]) particles and by using SMART particles. FA nanoparticles enhanced the entry and particle retention to the reticuloendothelial system over nondecorated polymers after systemic administration into mice. These data were seen by MRI testing and validated by comparison with SMART particles and direct evaluation of tissue drug levels after nanoART. The development of alendronate (ALN)-coated magnetite thus serves as a rapid initial screen for the ability of targeting ligands to enhance nanoparticle-antiretroviral drug biodistribution, underscoring the value of decorated magnetite particles as a theranostic tool for improved drug delivery.

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“…One common class of compounds are synthetic and natural hydrophilic polymers such as poly(ethylene glycol) (PEG) [16,17], poly(vinyl alcohol) (PVA) [18][19][20], poly(Llysine) (PLL) [21], poly(acrylic acid) (PAA) [22], dextran [23][24][25][26][27], alginate [28][29][30], chitosan [31][32][33], starch [34][35][36], and gum Arabic [37][38][39] to name a few. These materials are effective at creating a neutral and hydrophilic surface that can resist protein adsorption, however they also come with the drawback of increasing a particle's hydrodynamic size.…”

Section: Coating Agentsmentioning

confidence: 99%

Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology

Rosen¹,

Yoffe²,

Meerasa³

2011

J Nanomedic Nanotechnol

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Medical imaging technologies allow for the rapid diagnosis and evaluation of a wide range of pathologies. In order to increase their sensitivity and utility, many imaging technologies such as CT and MRI rely on intravenously administered contrast agents. While the current generation of contrast agents has enabled rapid diagnosis, they still suffer from many undesirable drawbacks including a lack of tissue specificity and systemic toxicity issues. Through advances made in nanotechnology and materials science, researchers are now creating a new generation of contrast agents that overcome many of these challenges, and are capable of providing more sensitive and specific information. In this review, we summarize the main classes of nanotechnology-based contrast agents for each of the major imaging technologies, and highlight progress in their development as well as the challenges to be addressed. We also review the relevant biological interactions that determine the in vivo fate of these contrast agents, and describe major themes in medical nanotechnology including stealth and targeting.

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Gum Arabic-Coated Magnetic Nanoparticles for Potential Application in Simultaneous Magnetic Targeting and Tumor Imaging

Cited by 116 publications

References 25 publications

Untitled

Untitled

Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy

Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology

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