Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility

Higuchi, Akon; Shirano, K.; Harashima, Masaharu; Yoon, Boo Ok; Hara, Mariko; Hattori, M.; Imamura, Kazuo

doi:10.1016/s0142-9612(01)00406-9

Cited by 233 publications

(136 citation statements)

References 16 publications

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“…The hydrophilicity of the Ti surface was measured as follows based on water contact angle analysis: pTi-D-pSBMA = pTi-SipSBMA > > Ti [88]. Hydrophilic surfaces showed better antifouling ability than less hydrophilic surfaces did in this study as well as in several reports published previously [89].…”

Section: Antimicrobial Surface Grafted With Antimicrobial Nanosegmentssupporting

confidence: 59%

Development of biomaterial surfaces with and without microbial nanosegments

Alarfaj¹,

Lee²,

Munusamy

et al. 2015

Journal of Polymer Engineering

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Abstract Infections by microorganisms are a major problem in public health throughout the world. Artificial materials, including biomedical goods, inherently lack defense against microbial development. Therefore, microbial cells can adhere on any type of artificial surface, particularly in a moist environment, and start to multiply to form a huge population. In this review, we will discuss a strategy for designing antimicrobial polymers and antimicrobial surfaces. Generally, there are five types of antimicrobial polymers: (a) polymeric biocides, (b) biocidal polymers, (c) biocide-releasing polymers, (d) bioactive oligopeptides, and (e) antimicrobial surfaces. Antimicrobial surfaces preventing the growth of microorganisms are a promising method to inhibit the spread of microbial infections. The antimicrobial surfaces can reject the attachment of microbes and/or kill microbes in the vicinity and can be designed to kill microbes on contact. It is recommended that the material surface not release biocidal substances, therefore preventing exhaustion of biocide release to kill microbes. Furthermore, the antimicrobial surfaces are desired to be nontoxic to human cells. The development of contact-active antimicrobial surfaces by grafting antimicrobial nanosegments onto the material surface will be an important topic in the future.

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Section: Antimicrobial Surface Grafted With Antimicrobial Nanosegmentssupporting

confidence: 59%

Development of biomaterial surfaces with and without microbial nanosegments

Alarfaj¹,

Lee²,

Munusamy

et al. 2015

Journal of Polymer Engineering

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“…The samples were washed with saline, subjected to a drying process by passing them through a series of graded alcohol-saline solutions (0, 25, 50, 75, and 100%), and dried in a vacuum for 10 h at room temperature. 22 The dried membranes after gold coating were examined using a JSM-5200 scanning electron microscope (JEOL, Ltd.).…”

Section: Scanning Electron Microscopy (Sem) Analysis Of Blood Cells Omentioning

confidence: 99%

Peripheral blood cell separation through surface‐modified polyurethane membranes

Higuchi

Yamamiya

Yoon

et al. 2003

J Biomedical Materials Res

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Cell separation from peripheral blood was investigated using surface-modified polyurethane (PU) membranes with different functional groups. Both red blood cells and platelets could pass through unmodified PU and PU-SO 3 H membranes, whereas the red blood cells preferentially passed through PU-N(C 2 H 5 ) 2 and PU-NHC 2 H 4 OH membranes. The permeation ratio of T and B cells was Ͻ25% for the surface-modified and unmodified PU membranes. CD34 ϩ cells have been recognized as various kinds of stem cells including hematopoietic and mesenchymal stem cells. The adhesiveness of CD34 ϩ cells on the PU membranes was found to be higher than that of red blood cells, platelets, T cells, or B cells. Overall, the adhesiveness of blood cells on the PU membranes increased in the following order: red blood cells Յ platelets Ͻ T cells Յ B cells Ͻ CD34 ϩ cells. Treatment of PU-COOH membranes with a human albumin solution to detach adhered blood cells, allowed recovery of mainly CD34 ϩ cells in the permeate, whereas both red blood cells and platelets could be isolated in the permeate using unmodified PU membranes. The PU membranes showed different permeation and recovery ratios of specific cells depending on the functional groups attached to the membranes.

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“…That is the reason why acidic proteins adhere easier to the dialyzer membranes. It was reported that adding PVP (polyvinyl pyrrolidone) or PEG (polyethylene glycol) hydrophilic groups can improve the hydrophobic characteristics of polysulfone membrane [30,31] . The mechanism of such improvement is in fact a certain degree of 'shielding' of the positively charged region.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

Yang

Zhu

2009

Blood Purif

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In order to study the mechanism of protein adhesion on the Fresenius F6 polysulfone membrane dialyzer, two-dimensional gel electrophoresis, LC-ESI-MS/MS and bioinformatics methods were used to analyze the protein which adhered to the dialyzer membrane. Six of the adhered proteins account for more than 50% of the total 179 proteins, i.e. ficolin precursor, complement C3 precursor, 3 variants of MASP1 and albumin. The results also showed that easily adhered proteins have a greater percentage of acidic amino acids (p < 0.01). The isoelectric point of the 20 proteins with the most deposits is 6.2 ± 1.08, which is obviously lower than of those with the least deposits (7.56 ± 1.36, p < 0.01). The dipole moment of a polysulfone membrane molecule has a tendency to absorb molecules with a negative charge. These results are of significance in understanding and improving membrane protein interactions.

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Chemically modified polysulfone hollow fibers with vinylpyrrolidone having improved blood compatibility

Cited by 233 publications

References 16 publications

Development of biomaterial surfaces with and without microbial nanosegments

Development of biomaterial surfaces with and without microbial nanosegments

Peripheral blood cell separation through surface‐modified polyurethane membranes

Characteristics and Molecular Mechanism of Adhesion Proteins on Reused Hemodialysis Membranes

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