Chemically Modified Natural Polysaccharides to Form Gels

Garner, John; Park, Kinam

doi:10.1007/978-3-319-16298-0_31

Cited by 12 publications

(10 citation statements)

References 103 publications

(95 reference statements)

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“…Polysaccharides, and more specifically, food polysaccharides [ 6 , 7 ], can also be crosslinked, either physically or chemically [ 8 , 9 , 10 ], to yield versatile matrices susceptible of being used as drug carriers [ 11 ], probiotic delivery systems [ 12 ], release systems for agrochemicals [ 13 ] or in food packaging [ 14 ], adsorbents in wastewater treatment [ 15 ], and even obtain ‘ordered’ hydrogels with additional potential capabilities [ 16 ]. Since it has been shown that most crosslinkers, such as the commonly used glutaraldehyde, can produce cytotoxic effects [ 10 ], poly(carboxylic acids) have been proposed instead.…”

Section: Introductionmentioning

confidence: 99%

Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin

Petitjean

Aussant

Vergara

et al. 2020

Gels

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The incorporation of cyclodextrins into polymeric crosslinked gels of hydrophilic nature can be useful for promoting the sorption of hydrophobic molecules and/or modulating the release of active principles. The covalent addition of these excipients to the matrix integrates their solubilizing effect that can contribute to increase the capacity of retention of hydrophobic substances. In this study, three diverse polysaccharides, chitosan, xanthan gum, and locust bean gum, were crosslinked with or without β-cyclodextrin, using citric acid in different ratios, to create hydrogel matrices. Through a green synthetic path, the efficient production of soluble and insoluble (hydrogel) networks functionalized with β-cyclodextrin was achieved by means of a solventless procedure. The characterization of their chemical composition, swelling in water, and their sorption and release behavior were also carried out in this work.

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Section: Introductionmentioning

confidence: 99%

Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin

Petitjean

Aussant

Vergara

et al. 2020

Gels

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“…Ionotropic gelation exploits the capability of polysaccharide-based polyelectrolytes to crosslink in the presence of counter ions under specific ranges of concentration and/or pH [107]. The ionic cross-linking of polysaccharide droplets in aqueous solution gives rise to hydrogel particles (or beads) characterized by a microstructure with interconnected nanofibrillar network [108][109][110][111]. Hydrogel physicochemical properties depend upon chemical composition of the selected polysaccharide, its concentration as well as the size (i.e., ionic radius) and the valence (i.e., coordination number) of counter ions and eventually, the presence of water of hydration surrounding cross-linking ions [2,112].…”

Section: Ionotropic Cross-linkingmentioning

confidence: 99%

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

et al. 2020

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Polysaccharide-based hydrogel particles (PbHPs) are very promising carriers aiming to control and target the release of drugs with different physico-chemical properties. Such delivery systems can offer benefits through the proper encapsulation of many drugs (non-steroidal and steroidal anti-inflammatory drugs, antibiotics, etc) ensuring their proper release and targeting. This review discusses the different phases involved in the production of PbHPs in pharmaceutical technology, such as droplet formation (SOL phase), sol-gel transition of the droplets (GEL phase) and drying, as well as the different methods available for droplet production with a special focus on prilling technique. In addition, an overview of the various droplet gelation methods with particular emphasis on ionic cross-linking of several polysaccharides enabling the formation of particles with inner highly porous network or nanofibrillar structure is given. Moreover, a detailed survey of the different inner texture, in xerogels, cryogels or aerogels, each with specific arrangement and properties, which can be obtained with different drying methods, is presented. Various case studies are reported to highlight the most appropriate application of such systems in pharmaceutical field. We also describe the challenges to be faced for the breakthrough towards clinic studies and, finally, the market, focusing on the useful approach of safety-by-design (SbD).

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“…The other areas where edible polymers based hydrogels were assessed for potential application includes wastewater treatment, − cosmetics applications, personal care products, − bioelectronics and biosensors, − industrial applications, − and so forth. Water is a vital resource for life, with only accounting 0.03% as usable for daily activities out of the total available on earth.…”

Section: Applications Of Edible Polymer Based Hydrogelsmentioning

confidence: 99%

Recent Advances in Edible Polymer Based Hydrogels as a Sustainable Alternative to Conventional Polymers

Ali

Ahmed²

2018

J. Agric. Food Chem.

238

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The over increasing demand of eco-friendly materials to counter various problems, such as environmental issues, economics, sustainability, biodegradability, and biocompatibility, open up new fields of research highly focusing on nature-based products. Edible polymer based materials mainly consisting of polysaccharides, proteins, and lipids could be a prospective contender to handle such problems. Hydrogels based on edible polymer offer many valuable properties compared to their synthetic counterparts. Edible polymers can contribute to the reduction of environmental contamination, advance recyclability, provide sustainability, and thereby increase its applicability along with providing environmentally benign products. This review is highly emphasizing on toward the development of hydrogels from edible polymer, their classification, properties, chemical modification, and their potential applications. The application of edible polymer hydrogels covers many areas including the food industry, agricultural applications, drug delivery to tissue engineering in the biomedical field and provide more safe and attractive products in the pharmaceutical, agricultural, and environmental fields, etc.

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Chemically Modified Natural Polysaccharides to Form Gels

Cited by 12 publications

References 103 publications

Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin

Solventless Crosslinking of Chitosan, Xanthan, and Locust Bean Gum Networks Functionalized with β-Cyclodextrin

Technologies and Formulation Design of Polysaccharide-Based Hydrogels for Drug Delivery

Recent Advances in Edible Polymer Based Hydrogels as a Sustainable Alternative to Conventional Polymers

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