Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

Houdová, Dominika; Soto, Juan; Castro, Rita; Rodrigues, João; Pino-González, Ma Soledad; Petković, Marijana; Bandosz, Teresa J.; Algarra, Manuel Martín

doi:10.1016/j.jcis.2021.02.004

Cited by 19 publications

(14 citation statements)

References 63 publications

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“…Information on optical parameters of the studied samples was obtained from spectroscopic ellipsometry (SE) and light transmission/reflection measurements, which are two non-destructive techniques used commonly for the characterization of layered and/or modified thin films [ 63 , 64 ]. Figure 4 shows the wavelength dependence of the refractive index (n) determined for the IL/NPAS samples, which were obtained from spectroscopic ellipsometry (SE) experimental parameters (angles Ψ and Δ) taking into account the ellipsometer software and the variation of tanΨ and cosΔ with wavelength for the three IL/NPAS is presented as Supplementary Information (Figure S4) ; for comparison, n values for the NPAS [ 39 ] are also indicated in Figure 4 .…”

Section: Resultsmentioning

confidence: 99%

Nanoporous Alumina Support Covered by Imidazole Moiety–Based Ionic Liquids: Optical Characterization and Application

et al. 2022

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This work analyzes chemical surface and optical characteristics of a commercial nanoporous alumina structure (NPAS) as a result of surface coverage by different imidazolium-based ionic liquids (1-butyl-3-metylimidazolium hexafluorophosphate, 3-methyl-1-octylimidazolium hexafluorophosphate, or 1-ethyl-3-methylimidazolium tetrafluoroborate). Optical characteristics of the IL/NPAS samples were determined by photoluminescence (at different excitation wavelengths (from 300 nm to 400 nm), ellipsometry spectroscopy, and light transmittance/reflectance measurements for a range of wavelengths that provide information on modifications related to both visible and near-infrared regions. Chemical surface characterization of the three IL/NPAS samples was performed by X-ray photoelectron spectroscopy (XPS), which indicates almost total support coverage by the ILs. The IL/NPAS analyzed samples exhibit different photoluminescence behavior, high transparency (<85%), and a reflection maximum at wavelength ~380 nm, with slight differences depending on the IL, while the refractive index values are rather similar to those shown by the ILs. Moreover, the illuminated I–V curves (under standard conditions) of the IL/NPAS samples were also measured for determining the efficiency energy conversion to estimate their possible application as solar cells. On the other hand, a computational quantum mechanical modeling method (DFT) was used to establish the most stable bond between the ILs and the NPAS support.

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Section: Resultsmentioning

confidence: 99%

Nanoporous Alumina Support Covered by Imidazole Moiety–Based Ionic Liquids: Optical Characterization and Application

et al. 2022

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“…CDs and N-CDs were prepared and characterized as previously described [ 22 , 23 ]. Organoruthenium complex, cyano(cyclopentadienyl)bis(triphenylphosphine)ruthenium(II), [Ru(η 5 -Cp)(PPh 3 ) 2 CN] (RuCN), was prepared by following a published method [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study

Nešić

Dučić

Algarra

et al. 2022

Cancers

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In the last decade, targeting membrane lipids in cancer cells has been a promising approach that deserves attention in the field of anticancer drug development. To get a comprehensive understanding of the effect of the drug [Ru(η5-Cp)(PPh3)2CN] (RuCN) on cell lipidic components, we combine complementary analytical approaches, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) and synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy. Techniques are used for screening the effect of potential metallodrug, RuCN, without and with drug carriers (carbon dots (CDs) and nitrogen-doped carbon dots (N-CDs)) on the lipids of the human ovarian cancer cell line A2780. MALDI TOF MS results revealed that the lysis of ovarian cancer membrane lipids is promoted by RuCN and not by drug carriers (CDs and N-CDs). Furthermore, SR-FTIR results strongly suggested that the phospholipids of cancer cells undergo oxidative stress after the treatment with RuCN that was accompanied by the disordering of the fatty acid chains. On the other hand, using (N-)CDs as RuCN nanocarriers prevented the oxidative stress caused by RuCN but did not prevent the disordering of the fatty acid chain packing. Finally, we demonstrated that RuCN and RuCN/(N-)CDs alter the hydration of the membrane surface in the membrane–water interface region.

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“…In this method, mass of ions is determined by the difference in flight times, where the ions with the same energy levels are directed towards the detector. MALDI-TOF MS provides accurate mass as good as 0.1 [155,164,165].…”

Section: Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometrymentioning

confidence: 99%

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

2021

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Carbon dots (CDs) are usually smaller than 10 nm in size, and are meticulously formulated and recently introduced nanomaterials, among the other types of carbon-based nanomaterials. They have gained significant attention and an incredible interest in the field of nanotechnology and biomedical science, which is merely due to their considerable and exclusive attributes; including their enhanced electron transferability, photobleaching and photo-blinking effects, high photoluminescent quantum yield, fluorescence property, resistance to photo-decomposition, increased electrocatalytic activity, good aqueous solubility, excellent biocompatibility, long-term chemical stability, cost-effectiveness, negligible toxicity, and acquaintance of large effective surface area-to-volume ratio. CDs can be readily functionalized owing to the abundant functional groups on their surfaces, and they also exhibit remarkable sensing features such as specific, selective, and multiplex detectability. In addition, the physico-chemical characteristics of CDs can be easily tunable based on their intended usage or application. In this comprehensive review article, we mainly discuss the classification of CDs, their ideal properties, their general synthesis approaches, and primary characterization techniques. More importantly, we update the readers about the recent trends of CDs in health care applications (viz., their substantial and prominent role in the area of electrochemical and optical biosensing, bioimaging, drug/gene delivery, as well as in photodynamic/photothermal therapy).

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Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

Cited by 19 publications

References 63 publications

Nanoporous Alumina Support Covered by Imidazole Moiety–Based Ionic Liquids: Optical Characterization and Application

Nanoporous Alumina Support Covered by Imidazole Moiety–Based Ionic Liquids: Optical Characterization and Application

Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study

Carbon Dots: Classification, Properties, Synthesis, Characterization, and Applications in Health Care—An Updated Review (2018–2021)

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