Chemical Variation in the Diterpenes from the Brazilian Brown Alga <i>Dictyota Menstrualis</i> (Dictyotaceae, Phaeophyceae)

Ortiz-Ramírez, Fredy A.; Cavalcanti, Diana Negrão; Villaça, Roberto Campos; Yoneshigue‐Valentin, Yocie; Teixeira, Valéria Laneuville

doi:10.1177/1934578x0800301117

Cited by 9 publications

(18 citation statements)

References 23 publications

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“…Ortiz‐Ramirez et al. () showed spatial variation with the quantity of diterpenes in Dictyota menstrualis , which enabled typical geographic patterns to be established for this species. Moreover, Fleury et al.…”

Section: Discussionmentioning

confidence: 99%

Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands

Lann

Kraffe

Kervarec³

et al. 2014

Journal of Phycology

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Several species of the genus Turbinaria coexist along the coasts of islands in the Indian and Pacific Oceans. Among these brown algae, Turbinaria ornata and T. conoides are sister species that are difficult to differentiate using exclusively morphological characters. Based on in vivo nuclear magnetic resonance and chromatographic techniques, i.e., liquid and gas chromatography-mass spectrometry analysis, combined with phylogenetic data, we successfully identified turbinaric acid in T. conoides samples from several Indian and Pacific Ocean islands. This nonvariable discriminant molecule was only identified in T. conoides specimens, but not in the two allied species T. ornata and T. decurrens. Results are discussed with regard to turbinaric acid as an interesting chemomarker isolated from T. conoides and the rapid discrimination of Turbinaria specimens using chemical assays.

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Section: Discussionmentioning

confidence: 99%

Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands

Lann

Kraffe

Kervarec³

et al. 2014

Journal of Phycology

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“…It is worthwhile to mention that the polarity of solvents may also influence the potency of some pharmacological effects, since different molecules can be extracted [40]. The extracts evaluated in this work contain nonpolar molecules, such as diterpenes, fatty acids or sterols.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products

et al. 2011

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The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders.

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“…The male and female gametophytes and the sporophyte are identical in appearance. In our previous studies conducted along the Brazilian littoral, it was observed in the field that different haploid-diploid ratios of the alternating life stages of D. menstrualis can be found at the same time in the field throughout the year (Cavalcanti et al 2006;Ortiz-Ramirez et al 2008;Pereira et al 2000;Teixeira et al 2001).…”

Section: Introductionmentioning

confidence: 97%

Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga Dictyota menstrualis

et al. 2010

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This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC-FID indicated a greater production of the diterpene in the female gametophytic phase (42.11 ppm). However, these individuals had the highest variation between individuals (standard deviation of 68.20 ppm in the range from 0.39 to 227 ppm). Sporophytic individuals showed less variability. This variability in the production of the antiviral diterpene is important to the development of future antiviral drugs.

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Chemical Variation in the Diterpenes from the Brazilian Brown Alga Dictyota Menstrualis (Dictyotaceae, Phaeophyceae)

Cited by 9 publications

References 23 publications

Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands

Isolation of turbinaric acid as a chemomarker of Turbinaria conoides (J. Agardh) Kützing from South Pacific Islands

Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products

Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga Dictyota menstrualis

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