Chemical Variation and <i>in vitro</i> Antibacterial Properties of Volatiles from Tunisian <i>Marrubium vulgare</i> L. (Lamiaceae)

Béjaoui, Afef; Salem, Intidhar Ben; Boulila, Abdennacer

doi:10.1080/0972060x.2017.1377118

Cited by 4 publications

(12 citation statements)

References 18 publications

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“…35 Monoterpenes hydrocarbons, terpinenes, have also shown antibacterial properties against bacterial strains. 36 The bridged bicyclic monoterpenes α-pinene and β-pinene showed considerable biological activity and a good therapeutic potential according to Salehi et al 37 Our results seems to be similar to those of other M. vulgare L. essential oils analyzed by Petrović et al 38 Intensive research has been conducted on the antibacterial activity of M. Vulgare L. 17,39 On the other hand, enantiomers of α-pinene, βpinene, limonene and linalool have a strong antibacterial activity. 40 The antimicrobial activities have been mainly explained through C10 and C15 terpenes with aromatic rings and phenolic hydroxyl groups able to form hydrogen bonds with active sites of the target enzymes, although other active terpenes, as well as alcohols, aldehydes and esters can contribute to the overall antimicrobial effect of essential oils.…”

Section: Antibacterial Activity Evaluationsupporting

confidence: 80%

Chemical Constituents, In Vitro Antibacterial Properties and Antioxidant Activity of Essential Oils from Marrubium vulgare L. Leaves

2021

TJNPR

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biological activities, such as analgesic, antihypertensive and antiedematogenic activity. 9 This species has been known as a remedy for upper respiratory tract ailments. Nowadays, horehound is used in herbal medicine for treatment of liver diseases, biliary tract disorders, and for increasing the appetite and supporting the function of the stomach. M. vulgare L., is reported to possess antioxidant activity, 10 and also as anti-inflammatory, 11 hypoglycemic 12 and vasorelaxant. 13 The essential oils from M. vulgare L. was already studied and showed a good antioxidant effectiveness, 14, 15 nociceptive, 16 antibacterial, 17 antifungal. 18 Nevertheless, there are few information on the antioxidant properties of horehound leaves essential oils. Moreover, there is no report on the chemical composition and antioxidant activity of the essential oils of horehound leaves from Morocco. Currently, the use of synthetic substances has been restricted in food because of its carcinogenic effect. Therefore, the search for new natural antioxidant sources has been greatly intensified. In the same context this study was performed to determine the chemical composition of the essential oils of M. vulgare L. leaves from Morocco and to evaluate their antibacterial properties and antioxidant activity. Materials and MethodsPlant material M. vulgare L. (Lamiaceae) used in this study have been collected between May and June 2019 in Fez-Morocco 34°03'50.1"N 5°02'13.3"W, and identified by Pr. Amina BARI botanist at the Sidi

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Section: Antibacterial Activity Evaluationsupporting

confidence: 80%

Chemical Constituents, In Vitro Antibacterial Properties and Antioxidant Activity of Essential Oils from Marrubium vulgare L. Leaves

2021

TJNPR

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“…It has been reported that M. vulgare plant possesses antioxidant, antifungal, hypoglycemic, and hypotensive activities [ 16 ]. The plant also exhibits antibacterial, antispasmodic, antinociceptive, and insecticidal activities [ 17 , 18 ]. M. vulgare also possess anticorrosion, anti-inflammatory, and vasorelaxant effects [ 19 – 21 ] and is considered as a good source of bioactive compounds with analgesic properties [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Mssillou

Agour

Hamamouch

et al. 2021

The Scientific World Journal

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In this study, the polyphenol content and the antioxidant and antimicrobial activities of hydroethanolic (MVE) and hydroacetonic (MVA) leaf extracts of Marrubium vulgare L. were examined. The results indicated that the total phenolic content was higher in MVA (112.09 ± 4.77 mg GAE/DW) compared to MVE extract (98.77 ± 1.68 mg GAE/DW). The total flavonoid content was also higher in MVA extract (21.08 ± 0.38 mg QE/g DW) compared to MVE (17.65 ± 0.73 mg QE/g DW). Analysis of the chemical composition revealed the presence of 13 compounds with a total of 96.14%, with the major compound being malic acid (22.57%). Both extracts possess a good total antioxidant activity. DPPH and FRAP assays indicated that the MVE extract possesses a better antioxidant activity, with IC50 = 52.04 µg/mL ± 0.2 and EC50 of 4.51 ± 0.5 mg/mL, compared to MVA extract (IC50 = 60.57 ± 0.6 µg/mL and EC50 of 6.43 ± 0.0411 mg/mL). Moreover, both extracts exhibited strong antimicrobial activity against certain nosocomial strains as indicted by the MIC values, which ranged between 0.93 mg/mL and 10 mg/mL. Taken together, these results reveal the importance of M. vulgare as a natural antioxidant with important antimicrobial activity.

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“…[46] Additionally, in another study, chemical compositions of EOs of M. vulgare were not associated with the bioclimatic zone. [16] Based on our results and literature, it seems that, the general secondary metabolites of M. vulgare are important as chemotaxonomic markers, but are also highly influenced by environmental conditions such as microclimate and abiotic conditions.…”

Section: Essential Oil Compositionmentioning

confidence: 56%

“…Pearson correlation analyses and Hierarchical cluster analyses (HCA) were performed with GraphPad Prism 9 and IBM SPSS Statistics Version 25 using Ward's method and Euclidean distance. [16,25,93] In all of statistical analyses, a value of p < 0.05 was considered as statistically significant.…”

Section: Discussionmentioning

confidence: 99%

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Chemical Profile and Cytotoxicity Evaluation of Aerial Parts of Marrubium vulgare L. From Different Locations in Turkey

Akbulut

Köse

Demırcı

et al. 2023

Chemistry & Biodiversity

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Marrubium vulgare L. (Lamiaceae) is used for respiratory and gastrointestinal system disorders in folk medicine. According to European Pharmacopoeia criteria, standardization of the plant is defined by its marrubiin content. In present study, phenolics, marrubiin and essential oil compositions of M. vulgare from different locations in Turkey were analyzed quantitatively by UPLC, GC and GC/MS. Besides, their cytotoxic potentials were evaluated.In the samples, forsythoside B (77 -400 mg/100 g dw), arenarioside (forsythoside F) (0-241 mg/100 g dw), verbascoside (acteoside) (171-416 mg/100 g dw) and apigenin-7-O-glucoside (0 -17 mg/100 g dw) were determined in different ranges. Marrubiin contents (0.58 -1.46 %) of some samples were two times higher than European Pharmacopoeia standards (0.7 %). β-Caryophyllene (7.24-20.34 %), (Z)-β-farnesene (1.58 -34.85 %), germacrene D (9.8-13.37 %), bicyclogermacrene (1.71-8.63 %) and β-bisabolene (0-16.68 %) were detected as major compounds in essential oils. The sample from the west of Aegean Region showed cytotoxicity against human neuroblastoma (SH-SY5Y) cell lines (IC 50 : 59.80 μg/mL) although it has no effect on non-cancerous NIH-3T3cell lines. This is the first report on phenolic profiles of M. vulgare populations from Turkey. Their potential as marrubiin source for pharmaceutical industry should be considered.

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Chemical Variation and in vitro Antibacterial Properties of Volatiles from Tunisian Marrubium vulgare L. (Lamiaceae)

Cited by 4 publications

References 18 publications

Chemical Constituents, In Vitro Antibacterial Properties and Antioxidant Activity of Essential Oils from Marrubium vulgare L. Leaves

Chemical Constituents, In Vitro Antibacterial Properties and Antioxidant Activity of Essential Oils from Marrubium vulgare L. Leaves

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.

Chemical Profile and Cytotoxicity Evaluation of Aerial Parts of Marrubium vulgare L. From Different Locations in Turkey

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