Chemical Synthesis of Ascorbyl Palmitate in [BMIM]BF&lt;sub&gt;4&lt;/sub&gt;

Ji, Jun Min

doi:10.4028/www.scientific.net/amr.236-238.1962

Cited by 2 publications

(2 citation statements)

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“…Industrially, the preferred system has been the chemical synthesis using concentrated sulfuric acid or hydrofluoric acid as catalyst. This is a process with high energy expenditure that results in the formation of by-products that hinder its purification [10]. More recently, the enzymatic synthesis using lipases as biocatalyst has been considered as an alternative for the synthesis of AsPa.…”

Section: Introductionmentioning

confidence: 99%

“…Downstream operations in the process of AsPa production have been scarcely explored. The chemical route for AsPa synthesis poses more difficulty to downstream because of the presence of several byproducts of the reaction that contaminate the product and must be removed [2,10]. In the enzymatic synthesis of AsPa, purification is also required but to a lesser extent, and fewer and less aggressive operations are required; in this case the task is merely the separation of AsPa from the residual substrates.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate

et al. 2019

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Ascorbyl palmitate is a fatty acid ester endowed with antioxidant properties, used as a food additive and cosmetic ingredient, which is presently produced by chemical synthesis. Ascorbyl palmitate was synthesized from ascorbic acid and palmitic acid with a Pseudomonas stutzeri lipase immobilized on octyl silica, and also with the commercial immobilized lipase Novozym 435. The latter was selected for optimizing the reaction conditions because of its high reactivity and stability in the solvent 2-methyl-2-butanol used as reaction medium. The reaction of the synthesis was studied considering temperature and molar ratio of substrates as variables and synthesis yield as response parameter. The highest yield in the synthesis of ascorbyl palmitate was 81%, obtained at 55 °C and an ascorbic acid to palmitic acid molar ratio of 1:8, both variables having a strong effect on yield. The synthesized ascorbyl palmitate was purified to 94.4%, with a purification yield of 84.2%. The use of generally recognized as safe (GRAS) certified solvents with a polarity suitable for the solubilization of the compounds made the process a viable alternative for the synthesis and downstream processing of ascorbyl palmitate.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%