2011
DOI: 10.1016/j.actbio.2011.03.004
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Chemical surface alteration of biodegradable magnesium exposed to corrosion media

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Cited by 183 publications
(135 citation statements)
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“…It could be shown that in cell culture environment degradation rates more similar to those observed in vivo could be obtained 8 . Moreover, in this artificial environment additional chemical reactions are taking place, which lead to a very complex degradation environment, also more comparable to the findings in vivo 5,6,[9][10][11] .…”
Section: Introductionsupporting
confidence: 64%
“…It could be shown that in cell culture environment degradation rates more similar to those observed in vivo could be obtained 8 . Moreover, in this artificial environment additional chemical reactions are taking place, which lead to a very complex degradation environment, also more comparable to the findings in vivo 5,6,[9][10][11] .…”
Section: Introductionsupporting
confidence: 64%
“…As was shown by earlier studies, Mg2+ facilitates calcification by stimulating the formation of calcium phosphates and thus decreases the amount of free Ca2+ in the surrounding medium. 10,20 In fact, all magnesium-based materials decreased the amount of Ca2+ in the solution. Pure Mg and Mg10Gd had a similar effect on Ca2+: first, a high decrease and then only slow further reduction, whereas WE43 and Mg2Ag had a constant rate of depletion.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that corrosion is faster in vitro than in vivo by several orders of magnitude.10 This can be explained by the presence of proteins and other organic molecules in blood that create a protective coating around magnesium, slowing down corrosion. 10 Thus, an addition of proteins in the form of fetal bovine serum (FBS) into the cell growth media would more closely imitate the in vivo environment than just using pure media. Dulbecco's Modified Eagle's Medium (DMEM) contains inorganic salts, calcium, amino acids and vitamins, and is thus very close to physiologic conditions.10…”
Section: Introductionmentioning
confidence: 99%
“…When using more complex media, such as cell growth media (e.g., Dulbeco's Modified Eagle Medium (DMEM) or Eagle's Minimum Essential Medium (EMEM)), the additional inorganic and organic compounds significantly alter 3 the corrosion behaviour [22]. Changing to solutions that in addition contain proteins also provides different results, which usually produces a decrease in the corrosion rate (e.g., [22][23][24][25]) and alters compositions of the corrosion layer [26]. If measurements are performed under cell culture conditions, the influence of O 2 and CO 2 is also observed, and the ratio of the resulting corrosion products is shifted compared to those under atmospheric conditions [27][28][29].…”
Section: Introductionmentioning
confidence: 99%