Chemical studies onGoniothalamus tapisMiq.

Abstract

Ten secondary metabolites were identified from Goniothalamus tapis Miq. The structures of these compounds were elucidated using spectroscopic analyses. It was revealed for the first time that 3-methyl-1H-benz[f]indole-4,9-dione was produced by the organism.

Inhibitory Effect of Compounds from Goniothalamus tapis Miq. and Goniothalamus uvaroides King on Platelet‐Activating Factor Receptor Binding

“…Recently, 10 compounds including 3‐methyl‐1 H ‐benz[ f ]indole‐4,9‐dione and cryptomeridiol were identified in G. tapis . However, the other compounds isolated differed from those isolated in this study as the previous study did not report the presence of styryl‐lactones but the presence of scorazanone, merioesinol and six phenanthrene lactams (Efdi et al ., ). Phytochemical study on the bark of G. uvaroides yielded compounds 1 , (+)‐goniopypyron ( 5 ) (Colegate et al ., ), (+)‐isogoniopypyrone ( 6 ) (Wang et al ., ) (+)‐isoaltholactone ( 7 ) (Colegate et al ., ), (+)‐goniofufurone ( 8 ) (Zhang et al ., ), 10 , 12 and dimethyl terephthalate ( 13 ) (DMT) (Fig.…”

“…Phytochemical investigation on Goniothalamus tapis resulted in the isolation of (+)‐goniothalamin ( 1 ) (Sam et al ., ), (+)‐9‐deoxygoniopypyrone ( 2 ) (Fang et al ., ), (+)‐goniodiol ( 3 ) (Fang et al ., ), (+)‐digoniodiol ( 4 ) (Lan et al ., ), (−)‐cryptomeridiol ( 9 ) (Ragasa et al ., (), liriodenine ( 10 ) (Hock and Jantan, ), 3‐methyl‐1 H ‐benz[ f ]indole‐4,9‐dione ( 11 ) (Efdi et al ., ) and (−)‐stigmasterol ( 12 ) (Kongduang et al ., ) (Fig. ).…”

“…They are used traditionally as postpartum protective remedies, abortifacient, typhoid fever, rheumatism, headache, insect repellent and to cure wounds (Burkill, ). Recently, 10 secondary metabolites including 3‐methyl‐1 H ‐benz[ f ]indole‐4,9‐dione were identified in G. tapis (Efdi et al ., ). Goniothalamin and 5‐acetyl goniothalamin have been isolated from the roots of G. uvaroides (Ahmad et al ., ).…”

ISOLASI DAN ELUSIDASI STRUKTUR SENYAWA TRITERPENOID DARI KULIT BATANG AMBACANG (Mangifera foetida L.) SERTA UJI BRINE SHRIMP LETALITY TEST (BSLT)

“…Senyawa 3-methyl-1H-benz[f]indole-4,9-dione (Goniothalamus tapis Miq.) juga aktif terhadap sel kanker tersebut [4] .…”

Bioactive Goniothalamin from <i>Goniothalamus tapis</i> with Cytotoxic Potential

“…The genus Goniothalamus comprises about 160 species (Wiart, 2007), growing in Asia and many of them are used as the traditional medicine in several countries (Surivet and Vatele, 1999;Wiart, 2007) such as Vallay fever Typhoid fever (root of G. tapis), Scabies (leaves of G. macrophyllus), Rheumatism, Tympanites (seeds of G. amuyon Merr) and stomachic (Efdi et al, 2010;Surivet and Vatele, 1999;Wiart, 2007). In Thailand, found nine species (Tip-Pyang et al, 2010).…”