Chemical studies on actinoxanthin.

Khokhlov, A. S.; Reshetov, P. D.; Chupova, L. A.; Cherches, B. Z.; Zhigis, L. S.; Stoyachenko, I. A.

doi:10.7164/antibiotics.29.1026

Cited by 32 publications

(11 citation statements)

References 14 publications

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“…Due to chromophore lability, currently only structures 1-5 are available. In contrast, the apoproteins were purified, the amino acid sequences of the apoproteins for neocarzinostatin (NcsA) (34,35), kedarcidin (Ked) (36,37), C-1027 (CagA) (38), actinoxanthin (AxnA) (39), maduropeptin (Mad) (36,40), and auromomycin (McmA) (41) were determined, and the corresponding genes, ncsA (42), cagA (43), axnA (44), and mcmA (45), were cloned and sequenced.…”

Section: Introductionmentioning

confidence: 99%

Enediyne Biosynthesis and Self-Resistance: A Progress Report

Thorson

Shen

Whitwam

et al. 1999

Bioorganic Chemistry

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Section: Introductionmentioning

confidence: 99%

Enediyne Biosynthesis and Self-Resistance: A Progress Report

Thorson

Shen

Whitwam

et al. 1999

Bioorganic Chemistry

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“…Among representatives of S. globisporus the producers of antitumor antibiotics lidamycin, landomycins and actinoxanthins, which also possess antibacterial properties, were described. Antifungal activity has not been previously described [23,24,25,26,27,28]. It is possible that strain S. globisporus INA 01180 forms one of these antibiotics, as well as an unidentified antifungal antibiotic.…”

Section: Resultsmentioning

confidence: 99%

Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda)

et al. 2018

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Because of the spread of drug resistance, it is necessary to look for new antibiotics that are effective against pathogenic microorganisms. The purpose of this study was to analyse the species composition of actinobacteria isolated from the digestive tract of the millipedes Nedyopus dawydoffiae and to determine their antimicrobial properties. Species identification was carried out on the basis of the morphological and culture properties and the sequence of the 16S rRNA gene. Actinobacteria were grown in different liquid media. Antibiotic properties were determined against some Gram-positive and Gram-negative bacteria as well as fungi. Of the 15 isolated strains, 13 have antibiotic activity against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus—MRSA) and fungi, but there was no antibiotic activity against Gram-negative test strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. It was established that antibiotic-producing actinobacteria belong to eight species of the genus Streptomyces. Depending on the nutrient medium, actinobacteria demonstrate different antimicrobial activities. As an example, S. hydrogenans shows that even strains selected in one population differ by the range of antimicrobial activity and the level of biosynthesis. Since the antibiotic production is considered as a feature for species competition in the microbiota community, the variability of antibiotic production among different strains of the same species is an adaptive characteristic for the competition in millipedes’ digestive tract community.

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“…The antitumor protein actinoxanthin was isolated from Actinomyces globisporus . The amino acid sequence of the apoprotein (AxnA) was determined [421,422]. The genes for actinoxanthin apoprotein (DIJ69_34170), transporters, and the UvrA-like protein are located on S. globisporus TFH56 plasmid pTFSG1 (GB No.…”

Section: Dna Synthesis Inhibitors and Related Antibioticsmentioning

confidence: 99%

Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria

Ogawara

2019

Molecules

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Antibiotic resistance poses a tremendous threat to human health. To overcome this problem, it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and pathogenic bacteria. This paper deals with this problem from four points of view. First, the antibiotic resistance genes in producers are discussed related to their biosynthesis. Most resistance genes are present within the biosynthetic gene clusters, but some genes such as paromomycin acetyltransferases are located far outside the gene cluster. Second, when the antibiotic resistance genes in pathogens are compared with those in the producers, resistance mechanisms have dependency on antibiotic classes, and, in addition, new types of resistance mechanisms such as Eis aminoglycoside acetyltransferase and self-sacrifice proteins in enediyne antibiotics emerge in pathogens. Third, the relationships of the resistance genes between producers and pathogens are reevaluated at their amino acid sequence as well as nucleotide sequence levels. Pathogenic bacteria possess other resistance mechanisms than those in antibiotic producers. In addition, resistance mechanisms are little different between early stage of antibiotic use and the present time, e.g., β-lactam resistance in Staphylococcus aureus. Lastly, guanine + cytosine (GC) barrier in gene transfer to pathogenic bacteria is considered. Now, the resistance genes constitute resistome composed of complicated mixture from divergent environments.

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Chemical studies on actinoxanthin.

Cited by 32 publications

References 14 publications

Enediyne Biosynthesis and Self-Resistance: A Progress Report

Enediyne Biosynthesis and Self-Resistance: A Progress Report

Antibiotic Activity of Actinobacteria from the Digestive Tract of Millipede Nedyopus dawydoffiae (Diplopoda)

Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria

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