Chemical Studies of Eucalyptus Tincture

Zhukovich, E. N.; Bobrenko, L. M.; Semenova, M. Yu.; Bokareva, S. Yu.

doi:10.1007/s11094-014-1103-x

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…[27] E. urnigera leaves also contained compounds 48a and 49, in addition to 5-hydroxy-7,4 0 -dimethoxy-6-methylflavone (48b). [28,29] Several flavonoids have been isolated from the leaves of E. viminalis, including the C-methyl flavones eucalyptin (48a) [27,29] and flavonoid 6,8-dimethyl-5,7-dihydroxy-4 0 -methoxyflavone. [29] Glycoside-containing quercetin (50) derivatives, including quercitrin (quercetin 3-a-L-rhamnopyranoside), hirsutrin (quercetin 3-b-D-glucopyranoside), and rutin (quercetin 3rutinoside) were also present.…”

Section: Eucalyptusmentioning

confidence: 99%

“…[28,29] Several flavonoids have been isolated from the leaves of E. viminalis, including the C-methyl flavones eucalyptin (48a) [27,29] and flavonoid 6,8-dimethyl-5,7-dihydroxy-4 0 -methoxyflavone. [29] Glycoside-containing quercetin (50) derivatives, including quercitrin (quercetin 3-a-L-rhamnopyranoside), hirsutrin (quercetin 3-b-D-glucopyranoside), and rutin (quercetin 3rutinoside) were also present. [30] Terpenoids have been obtained from E. viminalis leaves including the oleanane natural product maslinic acid (51), [31] lactone 49, [32] and cryptomeridiol (52).…”

Section: Eucalyptusmentioning

confidence: 99%

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Natural Products Isolated from Endemic Tasmanian Vascular Plants

Deans¹,

Salas²,

Smith³

et al. 2018

Aust. J. Chem.

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Tasmania is the south-eastern island state of Australia. It is geographically isolated and is recognised for both its rich diversity of plant species and high degree of endemism. Although 530 endemic Tasmanian vascular plant species are known, natural products have only been isolated from 27 of these species (~5.1 %), representing 3 classes (Dicotyledonae, Monocotyledonae, and Gymnospermae), 12 families, and 14 genera. Terpenoids, flavonoids, and alkaloids are the major classes of compound that have been isolated from these species. This report provides the first review of the natural products isolated from endemic Tasmanian plant species and covers ~70 years of research in this area.

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Section: Eucalyptusmentioning

confidence: 99%

Section: Eucalyptusmentioning

confidence: 99%

Natural Products Isolated from Endemic Tasmanian Vascular Plants

Deans¹,

Salas²,

Smith³

et al. 2018

Aust. J. Chem.

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“…Cryptomeridiol ( 8 ), an antispasmodic sesquiterpene, has been isolated from a wide variety of plant species, but its isolation from Eucalyptus tinctures derived from manna gum ( E. viminalis ) in 2014 was the first report from a eucalypt . Our isolation of cryptomeridiol from E. cloeziana therefore marks only its second report from a eucalypt.…”

Section: Resultsmentioning

confidence: 91%

α-Synuclein Aggregation Inhibitory and Antiplasmodial Activity of Constituents from the Australian Tree Eucalyptus cloeziana

Prebble,

Holland,

Ferretti

et al. 2023

J. Nat. Prod.

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Amyloid protein aggregates are linked to the progression of neurodegenerative conditions and may play a role in life stages of Plasmodium falciparum, the parasite responsible for malaria. We hypothesize that amyloid protein aggregation inhibitors may show antiplasmodial activity and vice versa. To test this hypothesis, we screened antiplasmodial active extracts from 25 Australian eucalypt flowers using a binding affinity mass spectrometry assay to identify molecules that bind to the Parkinson's disease-implicated protein α-syn. Myrtucommulone P (1) from a flower extract of Eucalyptus cloeziana was shown to have α-syn affinity and antiplasmodial activity and to inhibit α-syn aggregation. 1 exists as a mixture of four interconverting rotamers. Assignment of the NMR resonances of all four rotamers allowed us to define the relative configuration, conformations, and ratios of rotamers in solution. Four additional new compounds, cloeziones A−C (2−4) and cloeperoxide (5), along with three known compounds were also isolated from E. cloeziana. The structures of all compounds were elucidated using HRMS and NMR analysis, and the absolute configurations for 2−4 were determined by comparison of TDDFT-calculated and experimental ECD data. Compounds 1−3 displayed antiplasmodial activities between IC 50 6.6 and 16 μM. The α-syn inhibitory and antiplasmodial activity of myrtucommulone P (1) supports the hypothesized link between antiamyloidogenic and antiplasmodial activity.

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“…Eucalimin is a phytodrug constituent of triterpene phenol aldehyde and triterpenoid isolated from foliage and shoots of Eucalyptus viminalis Labill [ 187 ]. The coupling of phloroglucinol and sesquiterpene constituents is believed to be responsible for this and similar products [ 188 , 189 ]. This product is effective against the growth of Gram-positive bacteria, including clinical isolates of resistant bacteria.…”

Section: Preclinical and Clinical Studies On Antibacterial Effects Of Phytochemicalsmentioning

confidence: 99%

Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria

et al. 2021

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The extensive usage of antibiotics and the rapid emergence of antimicrobial-resistant microbes (AMR) are becoming important global public health issues. Many solutions to these problems have been proposed, including developing alternative compounds with antimicrobial activities, managing existing antimicrobials, and rapidly detecting AMR pathogens. Among all of them, employing alternative compounds such as phytochemicals alone or in combination with other antibacterial agents appears to be both an effective and safe strategy for battling against these pathogens. The present review summarizes the scientific evidence on the biochemical, pharmacological, and clinical aspects of phytochemicals used to treat microbial pathogenesis. A wide range of commercial products are currently available on the market. Their well-documented clinical efficacy suggests that phytomedicines are valuable sources of new types of antimicrobial agents for future use. Innovative approaches and methodologies for identifying plant-derived products effective against AMR are also proposed in this review.

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Chemical Studies of Eucalyptus Tincture

Cited by 6 publications

References 7 publications

Natural Products Isolated from Endemic Tasmanian Vascular Plants

Natural Products Isolated from Endemic Tasmanian Vascular Plants

α-Synuclein Aggregation Inhibitory and Antiplasmodial Activity of Constituents from the Australian Tree Eucalyptus cloeziana

Phytochemicals: A Promising Weapon in the Arsenal against Antibiotic-Resistant Bacteria

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