Chemical structure of poly(β‐cyclodextrin‐<i>co</i>‐citric acid)

Bednarz, Szczepan; Łukasiewicz, Marcin; Mazela, Wojciech; Pajda, M.; Kasprzyk, Wiktor

doi:10.1002/app.33002

Cited by 33 publications

(27 citation statements)

References 47 publications

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“…Such adsorbed carboxylate species [R (COO -) x ] ads can be interpreted as fingerprints of the original citrate ions that might have decompose under the temperature and pressure regime used for Hap synthesis, in line with the reports on citric acid thermal degradation[36][37][38][39] . The band at 1384 cm -1 may be ascribed to CH 2 scissoring and carboxylate groups differently coordinated to Hap surface under monodentate or bidentate configurations 6,30 may account for the bands at 1402, 1458, 1577 and 1669 cm -1 .…”

supporting

confidence: 68%

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

et al. 2015

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A novel synthetic approach for coupling metallic gold nanoparticles (AuNPs) to the facets of hydroxyapatite crystalline nanoparticles (HapNPs) without an additional reducing agent was developed. Hexagonal prism-shaped hydroxyapatite nanoparticles (HapNPs) were first precipitated by a hydrothermal route assisted by citric acid, which left behind carboxylate species adsorbed on the HapNP facets. HapNP were then used as templates for gold precipitation. Upon exposure to gold ions, the carboxylate species on the HapNP prismatic facets were able to trigger the nucleation of metallic gold by reducing the gold ions in situ. The used conditions did not allow for the extensive growth of gold nuclei and hence gold dots with diameters not larger than 2.5 nm were formed on the HapNP facets. The obtained (Hap–AuNP) heteronanostructures combine Hap nanoprisms, a highly biocompatible material easily recognised by the human body, with metallic nanosized gold that imparts a plasmon resonance (SPR) effect to the synthesized nanostructures, which is of great potential for further exploration within the contexts of thermotherapy and imaging strategies. Human mesenchymal stem cells were exposed to a range of Hap–AuNP concentrations, but no cytotoxic effects from the heteronanostructures were observed. Furthermore, Hap–AuNP greatly enhanced Runx2 and ALP expressions. In addition, these results predict that the synthesized Hap–AuNP particles could hold potential interest for medical applications requiring nontoxic materials capable of bone-defect repair and furthermore exhibiting SPR properties, which can be potentially advantageous for therapeutic and diagnostic purposes

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confidence: 68%

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

et al. 2015

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“…Therefore, we modified the surface of the electrospun PET nanofibers through the polymerization reaction between CTR and CD [21,24,25]. Water-insoluble cyclodextrin polymer (CDP) network was formed by the crosslinking reaction between CD and CTR [26]. Three different types of native CD (␣-CD, ␤-CD and ␥-CD) were used to form ␣-CDP, ␤-CDP and ␥-CDP.…”

Section: The Cdp Formation Onto Electrospun Pet Nanofibersmentioning

confidence: 99%

Surface modification of electrospun polyester nanofibers with cyclodextrin polymer for the removal of phenanthrene from aqueous solution

Kayacı

Aytaç

Uyar

2013

Journal of Hazardous Materials

130

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Cataloged from PDF version of article.Surface modified electrospun polyester (PET) nanofibers with cyclodextrin polymer (CDP) were produced (PET/CDP). CDP formation onto electrospun PET nanofibers was achieved by polymerization between citric acid (CTR, crosslinking agent) and cyclodextrin (CD). Three different types of native CD (α-CD, β-CD and γ-CD) were used to form CDP. Water-insoluble crosslinked CDP coating was permanently adhered onto the PET nanofibers. SEM imaging indicated that the nanofibrous structure of PET mats was preserved after CDP surface modification process. PET/CDP nanofibers have shown rougher/irregular surface and larger fiber diameter when compared to untreated PET nanofibers. The surface analyses of PET/CDP nanofibers by XPS elucidated that CDP was present on the fiber surface. DMA analyses revealed the enhanced mechanical properties for PET/CDP where PET/CDP nanofibers have shown higher storage modulus and higher glass transition temperature compared to untreated PET nanofibers. The surface area of the PET/CDP nanofibers investigated by BET measurements showed slight decrease due to the presence of CDP coating compared to pristine PET nanofibers. Yet, it was observed that PET/CDP nanofibers were more efficient for the removal of phenanthrene as a model polycyclic aromatic hydrocarbon (PAH) from aqueous solution when compared to pristine PET nanofibers. Our findings suggested that PET/CDP nanofibers can be a very good candidate as a filter material for water purification and waste treatment owing to their very large surface area as well as inclusion complexation capability of surface associated CDP

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“…The citrate contribution to the particle surface charge will be ruled by the amount of free carboxylate groups negatively charged, which in turn is conditioned by the citrate coordination mode to Hap surface. Moreover, it was already reported that citric acid may degrade at T .1458C [35,36] leading to reaction products that include different dehydroxylated or decarboxylated acids and anhydrides depending on the used heating rate and temperature. It is thus hypothesized that the original citrate ions do not exist as adsorbed species on the HS particle surface, but instead as smaller carboxylated ions resulting from citrate ion decomposition under the high temperature and pressure used for Hap hydrothermal synthesis.…”

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confidence: 99%

Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response

Santos

Gomes

Duarte

et al. 2012

J. R. Soc. Interface.

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Hydroxyapatite (Hap) is a calcium phosphate with a chemical formula that closely resembles that of the mineral constituents found in hard tissues, thereby explaining its natural biocompatibility and wide biomedical use. Nanostructured Hap materials appear to present a good performance in bone tissue applications because of their ability to mimic the dimensions of bone components. However, bone cell response to individual nanoparticles and/or nanoparticle aggregates lost from these materials is largely unknown and shows great variability. This work addresses the preparation and characterization of two different Hap nanoparticles and their interaction with osteoblastic cells. Hap particles were produced by a wet chemical synthesis (WCS) at 378C and by hydrothermal synthesis (HS) at 1808C. As the ultimate in vivo applications require a sterilization step, the synthesized particles were characterized 'as prepared' and after sterilization (autoclaving, 1208C, 20 min). WCS and HS particles differ in their morphological (size and shape) and physicochemical properties. The sterilization modified markedly the shape, size and aggregation state of WCS nanoparticles. Both particles were readily internalized by osteoblastic cells by endocytosis, and showed a low intracellular dissolution rate. Concentrations of WCS and HS particles less than 500 mg ml 21 did not affect cell proliferation, F-actin cytoskeleton organization and apoptosis rate and increased the gene expression of alkaline phosphatase and BMP-2. The two particles presented some differences in the elicited cell response. In conclusion, WCS and HS particles might exhibit an interesting profile for bone tissue applications. Results suggest the relevance of a proper particle characterization, and the interest of an individual nanoparticle targeted research.

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Chemical structure of poly(β‐cyclodextrin‐co‐citric acid)

Cited by 33 publications

References 47 publications

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

Gold-dotted hydroxyapatite nanoparticles as multifunctional platforms for medical applications

Surface modification of electrospun polyester nanofibers with cyclodextrin polymer for the removal of phenanthrene from aqueous solution

Relevance of the sterilization-induced effects on the properties of different hydroxyapatite nanoparticles and assessment of the osteoblastic cell response

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