Chemical Structure and Pharmacokinetics of Calcium Antagonists

Lydtin, H; Trenkwalder, Peter

doi:10.1007/978-3-642-74887-5_2

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Mechanism Of Action Hypertension2

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Cited by 2 publications

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“…All CCBs work in this way, although the DHPs (e.g. amlodipine, nifedipine) are the most potent vasodilators, and have the greatest affinity to vascular smooth muscle, thus they are the preferential agents in the treatment of hypertension (Lydtin & Trenkwalder, 1990).…”

Section: Mechanism Of Action Hypertensionmentioning

confidence: 99%

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Use of calcium channel blockers in cardiovascular disease

Bain

2019

British Journal of Cardiac Nursing

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Calcium channel blockers (CCBs) are widely used agents in the management of a number of cardiovascular indications, including hypertension, angina and supraventricular tachycardias. By inhibiting the movement of calcium into the cytoplasm via transmembrane calcium channels, they reduce vascular and myocardial contractility, and modulate the activity of pacemaker cells. There are important differences between the different types of calcium channel blockers, and a sound understanding of their mechanism of action is required to promote their safe, effective use. This article briefly describes calcium channel pharmacology, the mechanism of action of CCBs and their place in the therapy of cardiovascular disease.

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Section: Mechanism Of Action Hypertensionmentioning

confidence: 99%

“…Initial dosing should be low, titrated upwards if necessary in monthly intervals according to response (NICE 2018c). Calcium channel blockers have been shown to be effective in reducing blood pressure, often after the first dose or a few days' treatment (Lydtin & Trenkwalder, 1990;Trenkwalder, 2004).…”

Section: Mechanism Of Action Hypertensionmentioning

confidence: 99%