Use of calcium channel blockers in cardiovascular disease

Abstract

Calcium channel blockers (CCBs) are widely used agents in the management of a number of cardiovascular indications, including hypertension, angina and supraventricular tachycardias. By inhibiting the movement of calcium into the cytoplasm via transmembrane calcium channels, they reduce vascular and myocardial contractility, and modulate the activity of pacemaker cells. There are important differences between the different types of calcium channel blockers, and a sound understanding of their mechanism of action is required to promote their safe, effective use. This article briefly describes calcium channel pharmacology, the mechanism of action of CCBs and their place in the therapy of cardiovascular disease.

Effect of Amlodipine and l-Carnitin Separately and Collectively on Certain Body Parameters that Are Related to Bone Metabolism in Ovariectomized Albino Rats

“…Although drug therapies are available, women are interested in alternative/adjunct therapies to slow down the bone loss associated with ovarian hormone deficiency (8) . Amlodipine, is a type of calcium channel blocker commonly used to treat high blood pressure and coronary artery disease (9) . Amlodipine was patented in 1982 and approved for medical use in 1990.…”