Chemical structure and anti-inflammatory effect of polysaccharides obtained from infusion of Sedum dendroideum leaves

Oliveira, Ana Flávia de; Nascimento, Georgia Erdmann do; Iacomini, Marcello; Cordeiro, Lucimara M.C.; Cipriani, Thales R.

doi:10.1016/j.ijbiomac.2017.07.122

Cited by 30 publications

(11 citation statements)

References 40 publications

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“…13 Moreover, it has been demonstrated that arabinose and galactose contents may determine the biological activity of pectin. 14,15 In this sense, pectin from artichoke by-products, because of its high content of arabinose (127 mg g −1 of pectin) and galactose (24 mg g −1 of pectin), 16 can be an interesting natural product to analyse its anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

et al. 2019

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“…Furthermore, kaempferol, myricetin, and quercetin glycosides have been reported in species from the Crassulaceae family [30][31][32][33][34][35]. Myricetin, quercetin, and kaempferol aglycone from S. dendroideum have been linked to antioxidant, anti-inflammatory, antinociceptive, and gastroprotective activity [1,2,4,11].…”

Section: Discussionmentioning

confidence: 99%

“…S. dendroideum is a species commonly used in Brazilian and Mexican traditional medicine due to its analgesic, antimicrobial, and gastroprotective properties. Previous scientific reports proved its activity against pain (antinociceptive) in an induced peritonitis model, antioxidant activity used as a fresh leaf infusion, antiglycemic effect in diabetic mice, anti-inflammatory activity in vitro due to its ability to stimulate macrophages to produce cytokines, and gastroprotective effect in vivo [1][2][3][4]. ese properties are related to vegetal secondary metabolites, including flavonoids glycosides, tannins, kaempferol, quercetin, and phenols.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts

López-Montemayor

Zavala

Montalvo-Parra

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Sedum dendroideum has antioxidant effects that are beneficial for different diseases. We aimed to analyze the antiproliferative activity of S. dendroideum in human pterygium fibroblasts (HPFs). Methods. HPFs were treated for 24 h with 0–1000 μg/mL of S. dendroideum lyophilized to analyze its effect on cell viability using the CellTiter assay. RNA from HPF treated with 250 μg/mL of S. dendroideum lyophilized was isolated, and the expression of VEGF and CTGF genes was evaluated by qPCR. A dermal fibroblast cell line (HDFa) was used as a healthy control. The total phenolic content, antioxidant activity, and chemical profile of S. dendroideum lyophilized were determined. Results. Viability of HPF decreased after 24 h treatment of S. dendroideum in a dose-dependent manner. The expression of VEGF and CTGF significantly decreased ( P < 0.01 ) in HPF treated with 250 μg/mL of S. dendroideum when compared with untreated HPF. The total phenolic concentration in the S. dendroideum lyophilized was 33.67 mg gallic acid equivalents (GAE)/g. Antioxidant activity was 384.49 mM Trolox equivalents/mL. The main phenolic compounds identified by HPLC analysis were the kaempferol-3-O-glycoside, kaempferol-3-O-rhamnoside, kaempferol-3-O-neohesperidoside-7-O-α-rhamnopyranoside, and kaempferol-3-O-glycoside-7-O-rhamnoside. Conclusions. S. dendroideum decreases the proliferation of HPF and the expression of VEGF and CTGF. The phenolic compound concentration, antioxidant activity, and phytochemical profile may play a role in these effects.

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“…Sedum dendroideum is succulent plant that has been utilized to cure inflammatory diseases. Two pectic polysaccharides from the leaves of S. dendroideum were isolated [29]. The studies have shown the influence of pectic polysaccharides on the secretion of pro-inflammatory and anti-inflammatory cytokines by macrophages.…”

Section: Outline Of Biological Activities Of Pectic Polysaccharidesmentioning

confidence: 99%

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

et al. 2018

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Pectin is a polymer with a core of alternating α-1,4-linked d-galacturonic acid and α-1,2-l-rhamnose units, as well as a variety of neutral sugars such as arabinose, galactose, and lesser amounts of other sugars. Currently, native pectins have been compared to modified ones due to the development of natural medicines and health products. In this review, the results of a study of the bioactivity of pectic polysaccharides, including its various pharmacological applications, such as its immunoregulatory, anti-inflammatory, hypoglycemic, antibacterial, antioxidant and antitumor activities, have been summarized. The potential of pectins to contribute to the enhancement of drug delivery systems has been observed.

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Chemical structure and anti-inflammatory effect of polysaccharides obtained from infusion of Sedum dendroideum leaves

Cited by 30 publications

References 40 publications

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts

Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review

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