Chemical Self-Assembly of Multifunctional Hydroxyapatite with a Coral-like Nanostructure for Osteoporotic Bone Reconstruction

Abstract

Bone defects/fractures are common in older people suffering from osteoporosis. Traditional hydroxyapatite (HA) materials for osteoporotic bone repair face many challenges, including limited bone formation and aseptic loosening of orthopedic implants. In this study, a new multifunctional HA is synthesized by spontaneous assembly of alendronate (AL) and FeO onto HA nanocrystals for osteoporotic bone regeneration. The chemical coordination of AL and FeO with HA does not induce lattice deformation, resulting in a functionalized HA (Func-HA) with proper magnetic property and controlled release manner. The Func-HA nanocrystals have been encapsulated in polymer substrates to further investigate their osteogenic capability. In vitro and in vivo evaluations reveal that both AL and FeO, especially the combination of two functional groups on HA, can inhibit osteoclastic activity and promote osteoblast proliferation and differentiation, as well as enhance implant osseointegration and accelerate bone remodeling under osteoporotic condition. The as-developed Func-HA with coordinating antiresorptive ability, magnetic property, and osteoconductivity might be a desirable biomaterial for osteoporotic bone defect/fracture treatment.

Calcium Supplement by Tetracycline guided amorphous Calcium Carbonate potentiates Osteoblast promotion for Synergetic Osteoporosis Therapy

“…These results were also confirmed by the mean optical density (MOD) studies in Figure S3 . As a result, it was inferred that the beneficial effects of calcium supplement in reversing osteoporosis were also partially attributed to the BMP-2-induced osteoblast differentiation 42 , which finally resulted in synergistic osteoblast promotion with Sim for better osteoporosis therapy. As expected, the calcium supplement (using ACC) or osteoblast promotion (using Sim) significantly reduced the TRAP activity than that in OVX group.…”

Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection

“…In addition, Quan et al . [30] prepared a new multifunctional that HAP is synthesized by spontaneous assembly of alendronate and Fe 3 O 4 onto HAP nanocrystals, for osteoporotic bone regeneration, it can inhibit osteoclastic activity and promote osteoblast proliferation and differentiation. This indicated that Fe 3 O 4 alone or in combination with other materials was beneficial to enhance cell activity.…”

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

“…It was demonstrated that the presence of the paramagnetic nanoparticles in the hydroxyapatite scaffold induced the osteoblast growth and proliferation as a consequence of the modification of the osteoclast-derived exosomal cargo and of the reduction of the exosome uptake efficiency by osteoblasts. The positive effects induced by iron oxide superparamagnetic nanoparticles dispersed in the HA scaffolds both in vivo and in vitro experiments were even reported when the Fe 3 O 4 nanoparticles were co-dispersed in 3D HA matrix in the presence of alendronic acid (AA) [65], which is known to inhibit the osteoclast differentiation and to enhance the osteoblastic activity [66]. Further, the nanoparticles were capped by poly(ethylene glycol) functionalized with carboxyl groups in order to interact with calcium ion of HA.…”