Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection

Abstract

The treatment of bone defect after bone tumor resection is a great challenge for orthopedic surgeons. It should consider that not only to inhibit tumor growth and recurrence, but also to repair the defect and preserve the limb function. Hence, it is necessary to find an ideal functional biomaterial that can repair bone defects and inactivate tumor. Magnetic nanoparticles (MNPs) have its unique advantages to achieve targeted hyperthermia to avoid damage to surrounding normal tissues and promote osteoblastic activity and bone formation. Based on the previous stage, we successfully prepared hydroxyapatite (HAP) composite poly(lactic-co-glycolic acid) (PLGA) scaffolds and verified its good osteogenic properties, in this study, we produced an HAP composite PLGA scaffolds modified with MNPs. The composite scaffold showed appropriate porosity and mechanical characteristics, while MNPs possessed excellent magnetic and thermal properties. The cytological assay indicated that the MNPs have antitumor ability and the composite scaffold possessed good biocompatibility. In vivo bone defect repair experiment revealed that the composite scaffold had good osteogenic capacity. Hence, we could demonstrate that the composite scaffolds have a good effect in bone repair, which could provide a potential approach for repairing bone defect after bone tumor excision.

Development of Fe3O4 integrated polymer/phosphate glass composite scaffolds for bone tissue engineering

“…7c). 79,80 MNP integrated polymer/ceramic composite scaffolds exhibited better cell-material interaction because MNP stimulates cell proliferation and cell differentiation and bone formation. 81 Yang et al 82 optimization is needed to achieve hyperthermia temperature.…”

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

“…Alendronic acid is just one example of the several bio-polymers and bio-compounds mixed in the presence of HA and MNPs. For example, a poly(lactic-co-glycolic acid) derivative (PLGA), a bio-compatible copolymer widely used in the bone tissue engineering [ 67 ], functionalized by means of carboxyl groups able to interact with HA moiety, and ad hoc obtained superparamagnetic iron oxide (Fe 3 O 4 ) nanoparticles were proposed [ 68 ]. MNPs were obtained by means of the co-precipitation method and oleic acid, oleylamine and hexadecanol were used as capping agents and surfactant [ 67 ].…”

Development of Biopolymeric Hybrid Scaffold-Based on AAc/GO/nHAp/TiO2 Nanocomposite for Bone Tissue Engineering: In-Vitro Analysis

“…These bioactive ceramics are complicated to shape into a desired shape, like HAp, which has a long degradation time but low mechanical strength due to its brittle nature. Because of its favorable osteoconductivity, HAp, one of the substantial constituents of native bone, has been frequently used in bone tissue engineering [ 16 , 17 ]. In load-bearing applications, the porous structure of HAp cannot hold up.…”