Chemical profiling of pharmaceuticals by capillary electrophoresis in the determination of drug origin

Flurer, Cheryl L.; Wolnik, Karen A.

doi:10.1016/0021-9673(94)85223-5

Cited by 49 publications

(26 citation statements)

References 16 publications

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“…The possibility of the separation of three impurities (compound numbers 2, 15 and 21 in Table 2) has not been discussed in the report. Using a modified MEKC method, six impurities were separated within less than 10 min [120] which is shorter in comparison with a previous work of Flurer and Wolnik [7]. The MEKC method was compared with the pharmacopeial HPLC method.…”

Section: Chemotherapeutic Agentsmentioning

confidence: 98%

“…amoxycillin, ampicillin and penicillin V, and a number of degradation products within less than 22 min. No information on the identity of the impurities was given [7]. The third MEKC method for separating amoxycillin and its impurities used factorial design in which the optimized condition was 70 mM NaH 2 PO 4 , pH 6.0, 5% ACN and 125 mM SDS.…”

Section: Chemotherapeutic Agentsmentioning

confidence: 99%

“…This has been demonstrated for an antithrombotic drug candidate supplied by three manufacturers [5] by an HPLC method, for the impurity of aminoglycosides [6] and for antibiotics samples from different manufacturers [7] both by micellar electrokinetic chromatography (MEKC) methods.…”

Section: Introductionmentioning

confidence: 97%

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Impurity analysis of pharmaceuticals using capillary electromigration methods

Jouyban

Kenndler

2008

Electrophoresis

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This review deals with the determination of impurities in pharmaceuticals by electromigration methods in the capillary format. These separation methods are either based on the different effective mobility of the charged analytes (as in zone electrophoresis and isotachophoresis) or include hybrid methods such as micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and electrochromatography. The pharmaceutically active compounds under consideration belong to chemotherapeutic agents, central nervous system drugs, histamine receptor drugs, cardiovascular drugs, anticancer drugs, anti-inflammatory drugs and some other drugs. The review discusses about 150 publications from the period between 1980 and 2007 with special emphasis on the recent trends and gives details about the experimental conditions applied for analyses and the obtained analytical performance parameters.

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Section: Chemotherapeutic Agentsmentioning

confidence: 98%

Section: Chemotherapeutic Agentsmentioning

confidence: 99%

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Impurity analysis of pharmaceuticals using capillary electromigration methods

Jouyban

Kenndler

2008

Electrophoresis

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“…Both techniques have been successfully applied in pharmaceutical analysis to the quantitative determination of drug compounds in formulations [3], in biological matrices [4,5] and within routine quality control [6,7]. Related impurities have been separated with low limits of detection [8,9] and the detection of trace components has been applied to determine drug origin [10].…”

Section: Introductionmentioning

confidence: 99%

Determination of impurities in an acidic drug substance by micellar electrokinetic chromatography

Gilges

1997

Chromatographia

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SummaryA sensitive micellar electrokinetic chromatography method for the determination of impurities in SB-209247, a novel LTB4 antagonist, has been developed. Selectivity was optimised by systematic examination of the effects of the acetonitrile content in the separation buffer. Sensitivity and resolution was enhanced by focusing effects for both charged and neutral analytes achieved by a special sample buffer composition. Minor impurities well below 0.1% peak area ratio can be readily and reliably detected. The validity of the method has been successfully demonstrated with respect to reproducibility of peak area ratios and the linearity of a key impurity. A comparison with HPLC has shown the method has complementary selectivity and competitive sensitivity.

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“…Many of these problems were addressed by the introduction of gradient elution methods, 7 column switching, 8,9 electrochemical detection [10][11][12] (particularly for biomedical analyses), or chemiluminescence detection. 13 Some attempts have also been made to improve upon available analytical methods for the detection of erythromycin by the introduction of newer techniques such as capillary electrophoresis, 14 which, although demonstrated to effectively distinguish between manufacturing processes, still lacks the sensitivity and resolution needed to accurately quantify low levels of impurities.…”

Section: Introductionmentioning

confidence: 99%