Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg.

Abstract

Neuroprotective potential of V. teucrium and V. jacquinii methanol extracts was analyzed. Chemical analysis of investigated extracts showed the presence of phenolic acid derivatives, flavonoids and one secoiridoid. The detected flavonoids derived from flavones (luteolin and isoscutellarein in V. jacquinii; apigenin, isoscutellarein and luteolin in V. teucrium) and flavonol (quercetin in V. jacquinii). Acteoside was the dominant compound in V. jacquinii, while plantamajoside and isoscutellarein 7-O-(6‴-O-acetyl)-b-allosyl (1‴?2‴)-b-glucoside were the major phenolics in V. teucrium. Additionally, the antineurodegenerative activity was tested at concentrations of 25, 50, and 100 lg/ml using acetylcholinesterase (AChE) and tyrosinase (TYR) assays. The inhibition of both enzymes was achieved with the investigated extracts, ranging from 22.78 to 35.40% for AChE and from 9.57 to 16.38% for TYR. There was no statistical difference between the activities of the analyzed extracts. Our data indicate that V. teucrium and V. jacquinii may have beneficial effects against Alzheimer's and Parkinson's disease.

Endemic Veronica saturejoides Vis. ssp. saturejoides–Chemical Composition and Antioxidant Activity of Free Volatile Compounds

“…Kwak et al reported antioxidant activity for iridoid glucosides in which the ethanolic extract showed higher activity than Trolox [44]. In our previous study, we tested the DPPH activity of various extracts of V. spicata, and the IC50 value showed the highest activity in methanolic extracts of flowers and leaves with values of 8.21 ± 0.06 µg/mL and 8.69 ± 0.06 µg/mL, i.e., higher than the values for standards BHT and BHA according to the values in the study by Živković et al [10].…”

“…Mocan et al [43] confirmed the antioxidant activity for V. officinalis with TEAC method 157.99 ± 6.58 mg TE/g. Živković et al [10] tested methanolic extracts of V. teucrium and V. jacquinii and they were stronger than previously reported by Harput et al [42] for V. officinalis, with IC50 values of 28.49 ± 0.6 for V. teucrium and 37.63 ± 0.6 µg/mL for V. jacquinii, although both have lower activity than the standard (BHT-butylated hydroxytoluene and BHA-butylated hydroxyanisole) [10]. Kwak et al reported antioxidant activity for iridoid glucosides in which the ethanolic extract showed higher activity than Trolox [44].…”

“…Species of the genus Veronica are used in traditional medicine for the treatment of various diseases, including influenza, respiratory diseases and cancer, and as diuretics [9] because of their natural richness in phenolic compounds and iridoids. In recent years, some research has shown that species from this genus could also be used to treat mental disorders [10] and some types of diabetes [11].…”

Veronica austriaca L. Extract and Arbutin Expand Mature Double TNF-α/IFN-γ Neutrophils in Murine Bone Marrow Pool

“…In addition, an aqueous acetone extract from aerial parts of V. jaquinii has been studied by high-perfomance liquid chromatography with tandem mass spectrometry and various-compounds were found, among which chlorogenic and quinic acids, hyperoside and isoquercetin have been reported as dominant constituents [11]. Recently, Zivkovic et al 2017 [12] analyzed methanolic extract from the same species by applying a similar technique and the main detected flavonoids appeared luteolin, isoscutelarein and quercetin derivatives, and verbascoside (acteoside), forsythoside B, forsythenside K and leucoseptoside A were reported as major phenylethanoid glycosides.…”

The study of carboxylic acids in flowers and leaves of Veronica chamaedrys L. and Veronica teucrium L.

“…Thus, in vitro experiments have shown that water-acetone extract from this raw material inhibits the enzymes cyclooxygenase-1 and 12-lipoxygenase. Anti-inflammatory activity is positively correlated with the content of phenolic compounds, in particular baicalein, quercetin, hyperoside, isoquercetin, chlorogenic acid [5,6]. It was found that antibacterial activity against S. aureus and E. coli is shown by aqueous extracts containing free polyphenols, hydroxycinnamic acids and extracts containing the sum of iridoids [7,8].…”