Chemical profiling and anti-psoriatic activity of methanolic extract of <i>Andrographis nallamalayana</i> J.L.Ellis

Parlapally, Sunitha; Cherukupalli, Neeraja; Bhumireddy, Sudarshana Reddy; Prabhakar, S.; Ravindernath, Anisetti; Giri, Charu Chandra; Khareedu, Venkateswara Rao; Vudem, Dashavantha Reddy

doi:10.1080/14786419.2015.1054825

Cited by 27 publications

(21 citation statements)

References 22 publications

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“…An animal study showing the topical application of methanolic extract of Andrographis nallamalayana on psoriatic lesions showed alleviation of symptoms within 12 days. The extract contains α-tocopherol among other natural chemicals [54]. A case report detailed the efficacy of nutritional supplementation and diet manipulation without concomitant standard psoriasis treatment in a 36-year old female with psoriasis.…”

Section: Vitamin Ementioning

confidence: 99%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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Fat-soluble vitamins exhibit numerous routes of immune modulation and specifically alter a variety of pathways in psoriasis pathology. Psoriasis, a chronic immune-mediated disease, often requires a combination of topical, oral, and occasionally, subcutaneous or intravenous therapies making disease management complex. With the complexity of treatment, patient adherence is reduced. Vitamin supplementation as an adjunctive treatment would minimize potential adverse effects from systemic medication, increase patient adherence and decrease overall cost. While vitamin A and D are effective topically, oral supplementation is not currently a mainstay of therapy although data exists to support such supplementation. Data on vitamin E and K implicate the significant role each has in the alteration of the inflammatory cascade responsible for psoriasis. Research showing fat-soluble vitamin deficiency in psoriasis exists and presents greater evidence for oral vitamin treatment in addition to first-line therapies. This review presents the mechanism of action in psoriasis of each fat-soluble vitamin and the data on the efficacy of oral fat-soluble vitamin supplementation in psoriasis and systemic inflammation. We also present fat-soluble vitamin deficiency data shown in psoriasis patients. With the evidence of their targeted mechanism of action, efficacy data with oral supplementation, and evidence of deficiency in patients, oral fat-soluble vitamins should be considered as an adjunct to therapy in psoriasis patients.

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Section: Vitamin Ementioning

confidence: 99%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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“…β-Sitosterol (α-dihydrofucosterol) (31) is the most abundant phytosterol on human diet and possess significant effect in relieving menopausal symptoms and reducing blood cholesterol levels by blocking the intestinal uptake. [86][87][88] Encountered in leaves, flowers and fruits, largely distributed throughout the Plantae kingdom, [89][90][91] this metabolite has a similar structure to estradiol and cholesterol, showing important anti-inflammatory and analgesic properties, [92][93][94] as well as antitumoral effects, such as minimizing symptoms of prostatic hyperplasia. 95 In recent study, it also has a significant concentrationdependent inhibition against induced-Epstein-Barr virus antigen, at low toxicity rates.…”

Section: Steroidsmentioning

confidence: 99%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms.

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“…The genomic and metabolite studies when combined with various bioinformatic analysis brings out the unknown diterpenoid scaffolds and the enzyme information (Andersen-Ranberg et al, 2016). In our laboratory, we have a comprehensive research programme on A.paniculata distribution, enhanced production of bioactive compound andrographolide and study of key enzymes/proteins (Neeraja et al, 2015;Parlapally et al, 2015;Zaheer and Giri, 2015;Zaheer et al, 2017a;Zaheer et al, 2017b;;Bindu et al, 2017;Srinath et al, 2017). In the present communication, in silico studies such as structural, functional features and the evolutionary relationship were elucidated using various bioinformatics tools.…”

Section: Introductionmentioning

confidence: 99%

In silico structural and functional analysis of copalyl diphosphate synthase enzyme in Andrographis paniculata (Burm. f.) Wall. ex Nees: A plant of immense pharmaceutical value

Shailaja¹,

Bindu²,

Srinath³

et al. 2018

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Andrographis paniculata (Burm. f.) Wa ll. ex Nees (Acanthaceae) with immense medicinal importance lacks information on its biosynthetic pathway genes and their regulatory role in the production of pharmaceutically important andrographolide. Copalyl diphosphate synthase (CPS) is involved in the production of copalyl diphosphate, a precursor for many bioactive compounds with particular reference to diterpene lactone. In this study, we elucidated the structural and functional aspects of A. paniculata CPS (ApCPS). Composition of amino acids and hydrophobic nature of ApCPS were analysed and identified as non trans-membrane protein. A chloroplast transit peptide and mitochondrial targeting peptide in ApCPS were identified. Protein secondary structure prediction has given insight on the distribution of helix (52.52%), loop (45.91%) and strands (1.56%) in ApCPS. The homology modelling of ApCPS was carried out with SWISS MODEL. The validation of 3D model using PROCHECK revealed that 91.74% of the residues have averaged 3D-1D score >= 0.2 which is structurally reliable. In Ramachandran plot, 90.9% amino acid residues were found in most favoured region. Phylogenetic tree was constructed using MEGA 7.0 by taking eudicots, monocots, gymnosperms and fungal species. Among them, ApCPS was clustered within eudicots and closely related to Sesumum indicum in Laminales. Protein-protein interaction study using STRING10 revealed that CPS interacts with gibberilic acid and terpene synthase related proteins. In Arabidopsis thaliana, CPS coexpression was seen with gibberelic acid related proteins. The present in silico analysis will be useful in understanding the structural, functional and evolutionary diversification of ApCPS.

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Chemical profiling and anti-psoriatic activity of methanolic extract of Andrographis nallamalayana J.L.Ellis

Cited by 27 publications

References 22 publications

Psoriasis and Fat-soluble Vitamins: A Review

Psoriasis and Fat-soluble Vitamins: A Review

Update: Biological and Chemical Aspects of Senna spectabilis

In silico structural and functional analysis of copalyl diphosphate synthase enzyme in Andrographis paniculata (Burm. f.) Wall. ex Nees: A plant of immense pharmaceutical value

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