Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction

Nasrin, Suaad; Islam, Mohammad Nazmul; Tayab, Mohammed Abu; Nasrin, Mst. Samima; Siddique, Md. Abu Bakar; Emran, Talha Bin; Reza, A. S. M. Ali

doi:10.1016/j.biopha.2022.112842

Cited by 24 publications

(19 citation statements)

References 94 publications

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“…Oxidation is responsible for many diseases related to pain such as cancer, infection, arthritis, cardiovascular diseases and type‐2 diabetes 16 . Antioxidant containing chemical compounds have been shown to reduce oxidation in cells of the body 26 . In the present study, we evaluated the antioxidant effect of MECVB.…”

Section: Discussionmentioning

confidence: 98%

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Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Jahan

Sakib

Alam

et al. 2022

Anim Models and Exp Med

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Background: Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal values. The present study aimed to explore the pharmacological activities of bark methanol extract using in vitro, in vivo and in silico models. Methods:The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark (MECVB) through in vitro, in vivo and in silico assays. Analgesic activity was tested using formalin-induced nociception and acetic acid-induced writhing assays while the antipyretic effect was tested using yeast-induced hyperthermia in mice model. The antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality bioassay. In addition, in silico studies were conducted using computer aided methods. Results:In the acetic acid-induced writhing assay, the extract showed 28.36% and 56.16% inhibition of writhing for doses of 200 and 400 mg/kg, respectively. Moreover, a dose-dependent formalin-induced licking response was observed in both early and late phase. In yeast-induced pyrexia, the MECVB exhibited (p < 0.05) antipyretic effect. The extract demonstrated an IC 50 value of 78.86 μg/ml compared with ascorbic acid (IC 50 23.53 μg/ml) in the DPPH scavenging assay. The compounds sitosterol, 5,7-dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX-I (2OYE), COX-II (6COX) and human peroxiredoxin 5 (1HD2). In ADME/T analysis, 5,7-dimethoxycoumarin and scopoletin satisfied Lipinski's rule of five and thus are potential drug candidates. Conclusion:The bark of Chukrasia velutina showed significant analgesic and antipyretic properties and is a potential source of natural anti-oxidative agents.

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Section: Discussionmentioning

confidence: 98%

“… 16 Antioxidant containing chemical compounds have been shown to reduce oxidation in cells of the body. 26 In the present study, we evaluated the antioxidant effect of MECVB. The antioxidant potency of the extract was demonstrated using the DPPH scavenging free radical assay, total phenol content and the reducing power assay.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Jahan

Sakib

Alam

et al. 2022

Anim Models and Exp Med

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“…Due to the unwanted adverse effects of synthetic medications, herbal therapies are becoming more popular in underdeveloped nations [ 7 ]. Plants are now thought to have substantial therapeutic potential due to their distinct characteristics as a key source of medicinal phytocompounds that might aid in developing innovative medication [ [30] , [31] , [32] , [33] ].…”

Section: Discussionmentioning

confidence: 99%

“…However, many of the recognized therapy choices for depression are linked with negative side effects. Consequently, new antidepressant drugs are crucial to prevent these side effects [ 7 ]. Ever more medicinal products are being developed from natural resources in recent years.…”

Section: Introductionmentioning

confidence: 99%

“…Ever more medicinal products are being developed from natural resources in recent years. It is possible to discover novel medicinal compounds using mushrooms and their secondary metabolites as a strong source [ [7] , [8] , [9] ] because, mushrooms have been a part of people's diets worldwide for decades because of its nutritional values and organoleptic properties [ 10 ]. In nature, there are over 150,000 distinct varieties of mushrooms in the environment; only 10% of them are identified and labeled [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations

Hossen¹,

Yusuf²,

Emon³

et al. 2022

Biochemistry and Biophysics Reports

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Luminous blue carbon quantum dots employing Anisomeles indica (catmint) induce apoptotic signaling pathway in triple negative breast cancer (TNBC) cells

Kumar,

Mahalakshmi,

Anitha

et al. 2024

Luminescence

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Herein, luminous blue carbon quantum dots (CDs) employing Anisomeles indica (Catmint) were reported with imaging, self‐targeting, and therapeutic effects on triple‐negative breast cancer (TNBC, MDA‐MB‐231) cells. The salient features of CDs generated from catmint are as follows: i) optical studies confirm CDs with excitation‐dependent emission; ii) high‐throughput characterization authenticates the formation of CDs with near‐spherical shape with diameter ranging between 5 and 15 nm; iii) CDs induce cytotoxicity (3.22 ± 0.64 μg/ml) in triple‐negative breast cancer (TNBC, MDA‐MB‐231) cells; iv) fluorescence microscopy demonstrates that CDs promote apoptosis by increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential; v) CDs significantly up‐regulate pro‐apoptotic gene expression levels such as caspases‐8/9/3. Finally, our work demonstrates that catmint‐derived CDs are prospective nanotheranostics that augment cancer targeting and imaging.

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Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction

Cited by 24 publications

References 94 publications

Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Pharmacological insights into Chukrasia velutina bark: Experimental and computer‐aided approaches

Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations

Luminous blue carbon quantum dots employing Anisomeles indica (catmint) induce apoptotic signaling pathway in triple negative breast cancer (TNBC) cells

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