Biochemical and Pharmacological aspects of Ganoderma lucidum: Exponent from the in vivo and computational investigations

Hossen, S. M. Moazzem; Yusuf, Ayda T.; Emon, Nazim Uddin; Alam, Najmul; Sami, Saad Ahmed; Polash, Shajjad Hossain; Nur, Md Arifuzzaman; Mitra, Saikat; Uddin, Mohammad Helal; Emran, Talha Bin

doi:10.1016/j.bbrep.2022.101371

Cited by 2 publications

(1 citation statement)

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“…The wooden barrier had a round hole that was 3.5 cm in diameter and 7.5 cm high. At 0, 30, 90, and 120 min, the number of times the mice passed through the opening between the two chambers was recorded using a tally counter for a period of 3 min (Hossen et al., 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Unveiling the pharmacological potential of Coelogyne suaveolens: An investigation of its diverse pharmacological activities by in vivo and computational studies

Eva,

Mamurat,

Rahat

et al. 2023

Food Science & Nutrition

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The medicinal potential of Coelogyne suaveolens, a traditional medicinal plant, was investigated through in vivo and molecular docking studies. The ethyl acetate fraction of the plant's acetonic extract was subjected to various bioactivity tests to assess its analgesic, anxiolytic, and sedative effects on Swiss albino mice. Furthermore, we used GCMS to identify the bioactive chemicals in the extract's ethyl acetate fraction. The root and bulb extracts demonstrated significant analgesic activity in acetic acid‐induced writhing, hot plate, and tail immersion tests in a dose‐dependent manner when compared to the control. Again, the extract exhibited moderate anxiolytic activity in the elevated plus maze test at a dosage of 400 mg/kg body weight, while the root extract showed significant anxiolytic activity in the hole board test at the same dosage. Significant sedative activity was observed in the hole cross, open field, and rotarod tests at a dosage of 400 mg/kg. According to molecular docking studies, the extract has the potential to serve as an analgesic medication by reducing the enzymatic activity of cyclooxygenases 1 and 2. Overall, the findings suggest that C. suaveolens has substantial therapeutic potential for the development of novel treatments for pain, anxiety, and sleep disorders.

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Section: Methodsmentioning

confidence: 99%