Chemical processing for production of no-carrier-added selenium-73 from germanium and arsenic targets and synthesis of l-2-amino-4-([73Se]methylseleno) butyric acid (l-[73Se]selenomethionine)

Plenevaux, Alain; Guillaume, Marcel; Brihaye, C.; Lemaire, Christian; Cantineau, R.

doi:10.1016/0883-2889(90)90060-t

Cited by 28 publications

(17 citation statements)

References 9 publications

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“…selenium-75, which was extracted into benzene following procedures earlier described in detail. 17,18 The radiosynthesis described below was conducted under argon in a conical 5 ml reaction vessel equipped with a magnetic stirring bar and a teflon rubber septum.…”

Section: Methodsmentioning

confidence: 99%

First no‐carrier‐added radioselenation of an adenosine‐A₁ receptor ligand

Blum

Neumaier

Wutz

et al. 2004

Labelled Comp Radiopharmac

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SummaryThe precursor synthesis and the no-carrier-added (n.c.a.) radiosynthesis of the adenosine-A 1 receptor ligand 5Se]1) are described in this report. A method was developed starting from elemental n.c.a. selenium-75, followed by a three-step polymer-supported radioselenation and deprotection which gave the radioligand with a radiochemical yield of 30%, a radiochemical purity of >99% and a specific radioactivity of >300 GBq/mmol (8 Ci/ mmol). Preparation time was 40 min. The nonradioactive compound 5 0 -(methylseleno)-N 6 -cyclopentyladenosine (1) was pharmacologically evaluated in vitro and showed high affinity and selectivity for the adenosine-A 1 receptor. These preliminary results suggest that this compound could be a useful radioligand for the noninvasive imaging of the brain adenosine-A 1 receptors using positron emission tomography (PET) when labelled with the positron emitter selenium-73 (half-life: 7.1 h).

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Section: Methodsmentioning

confidence: 99%

First no‐carrier‐added radioselenation of an adenosine‐A₁ receptor ligand

Blum

Neumaier

Wutz

et al. 2004

Labelled Comp Radiopharmac

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“…3,6] it appeared to us that there is still considerable need of improvement in targetry and chemical processing methods, particularly in the case of no-carrier added radioselenium.…”

Section: Production Routesmentioning

confidence: 98%

“…The solution was then heated to 85 °C for 30 min. Thereafter it was quickly cooled, benzene was added and the extraction done for 1 h. The extraction conditions were thus essentially the same as described by Plenevaux et al [6]. The extraction yield of radioselenium was, however, very low.…”

Section: Extraction Behaviour Of Radioseleniummentioning

confidence: 99%

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Thermochromatographic Separation of Radioselenium from Irradiated Cu3As-target: Production of no-carrier added 75Se

Blessing¹,

Lavi²,

Hashimoto³

et al. 1994

Radiochimca Acta

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No-carrier added 75 Se / High current targetry / Thermochromatography / Solvent extraction / Radionuclide purity / Chemical reactivity SummaryNo-carrier added 75 Se (Γ 1/2 = 120 d) was produced with a highcurrent Cu 3 As-target via the 75 As(p,n)-reaction. A two-step thermochromatographic method using 0 2 as the purging gas was developed to separate radioselenium which was taken up in 6 Μ HCl. A 4 h irradiation with protons (E p = 17 0 MeV) at a beam current of 20 μΑ led to about 37 MBq (1 mCi) of no-carrier added 75 Se. The product was of high radionuclidic purity and predominantly consisted of 75 SeOf . After reduction with S0 2 , the radioactive species was efficiently extracted in benzene and showed high chemical reactivity. The extraction behaviour of radioselenium in benzene was found to be strongly influenced by the arsenic concentration in the solution.

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“…[1][2][3][4] The decay characteristics of 75 Se are not ideal for in vivo application, because the radiation absorbed dose delivered to the patient in a study is high and the images with conventional g-cameras are of poor quality. 5 The nuclear properties of 73 Se (T 1=2 ¼ 7.1 h; 65% b + ; 35% EC) suggest that it may be a more useful label for in vivo medical applications using positron-emission-tomography (PET). This radioisotope can be produced in sufficient amounts via the 75 As(p, 3n) 73 Se reaction.…”

Section: Introductionmentioning

confidence: 99%