Chemical preparation of beta calcium sulfate hemihydrate granules with a special particle size as bone graft material

Sargolzaie, Naser; Taghavi, Amir Moeen; Saghravanian, Nasrollah; Ahmadpour, Ali; Sargolzaei, Javad; Mohiti, Amir Khosro; Forouzanfar, Ali

doi:10.1016/j.clinbiochem.2011.08.442

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“…In some other studies using calcium sulfate for the repair of bone defects, there has been no evidence of inflammation, in contrast to this study. 22,23,29 On the other hand, in a study by Sargolzaie et al 19 on the preparation of hemihydrate calcium sulfate granules and its histological evaluation, the results were consistent with the present study and revealed inflammation. In that study, calcium sulfate granules were prepared from pure calcium sulfate powder and a binder.…”

Section: Discussionsupporting

confidence: 93%

“…With the aim of slowing down the resorption rate of calcium sulfate, Sargolzaie et al 19 prepared hemihydrate calcium sulfate granules with a size of 500−700 µm and suitable hardness of dehydrate calcium sulfate powder, which was used to repair bone defects in the skull of rabbits. The results of that study showed that hemihydrate calcium sulfate granules had good biocompatibility and promoted bone healing.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effect of hemihydrate calcium sulfate granules and Cerabone on dental socket preservation: An animal experiment

Sargolzaie

Rafiee²,

Sedigh

et al. 2018

J Dent Res Dent Clin Dent Prospects

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Background. Early bone loss due to tooth extraction can be significantly reduced by socket preservation. The aim of this study was to compare the in vivo effects of hemihydrate calcium sulfate granules (an alloplastic material) and Cerabone (a bovine-derived xenograft) on socket preservation in dogs. Methods. Six male Mongrel dogs were randomly divided into 2 groups (n=3) for sacrificing and histological evaluation 4 and 8 weeks after a surgery. The second and third premolars on both sides of the lower jaw were extracted surgically. The sockets on one side were filled with Cerabone, and with calcium sulfate on the opposite side. In the slides, the ratio of the area of newly formed bone to the area of the entire cavity, and the ratio of the area of fibrous connective tissue to the area of the entire cavity were measured. The presence of inflammation was also examined. Wilcoxon signed-rank test, Sign test and McNemar test were used for statistical analyses (ɑ=0.05). Results. The means of new bone proportion were 11% and 8% for Cerabone and calcium sulfate, respectively (P=0.58). The means of connective tissue proportion were 29% and 33% for Cerabone and calcium sulfate, respectively (P=0.72). No inflammatory cells were observed in the Cerabone group, although 50% of the samples in the calcium sulfate group showed inflammation (P=0.50). Conclusion. The effects of calcium sulfate and Cerabone on socket preservation in dogs on bone formation, fibrous connective tissue and inflammation levels were not significantly different at 4- and 8-week postoperative intervals.

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