Chemical patterning in biointerface science

Ogaki, Ryosuke; Alexander, Morgan R.; Kingshott, Peter

doi:10.1016/s1369-7021(10)70057-2

Cited by 74 publications

(53 citation statements)

References 152 publications

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“…[1][2][3][4][5][6][7][8] Compared with two-dimensional polymer nanoarrays, which can be routinely fabricated by many nanotechnologies, fabrication of arbitrary 3D polymer structures is much more challenging and remarkably complex because of the simultaneous alignment of in-plane lateral spacings and out-of-plane heights. In the last few years, 3D nanopatterns of polymers have been obtained by scanning probe nanomachining which relies on multiple cycles of serial top-down etching steps of organic resists.…”

mentioning

confidence: 99%

“…We first demonstrate how to fabricate polymer gradients, which are important templates to understand the binding behavior in many biological processes. [3,5,8,26] The key step is to generate arrays of nanobrushes with gradual change in their dot-to-dot spacing. This gradual change can be readily achieved by converting a gray-scale gradient image into a density varying black-and-white bitmap with defined pixel number and pixel distance.…”

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confidence: 99%

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Fabrication of Arbitrary Three‐Dimensional Polymer Structures by Rational Control of the Spacing between Nanobrushes

et al. 2011

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confidence: 99%

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confidence: 99%

Fabrication of Arbitrary Three‐Dimensional Polymer Structures by Rational Control of the Spacing between Nanobrushes

et al. 2011

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“…Due to this limitation, bioactive hydrogel systems can only be designed at this time by trialand-error; typically by the application of high-throughput methods. 11,12 However, because the design space for these complex materials is effectively infinitely large, such trialand-error approaches still have very limited potential to identify optimal hydrogel designs, thus, in reality, still being rather inefficient. This problem can be surmounted by the development of methods that provide the ability to accurately represent and visualize a hydrogel's molecular structure and assess the presentation of tethered bioactive segments.…”

Section: Introductionmentioning

confidence: 99%

Multiscale approach for the construction of equilibrated all-atom models of a poly(ethylene glycol)-based hydrogel

Murthy

Becker

et al. 2016

Biointerphases

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A multiscale modeling approach is presented for the efficient construction of an equilibrated allatom model of a cross-linked poly(ethylene glycol) (PEG)-based hydrogel using the all-atom polymer consistent force field (PCFF). The final equilibrated all-atom model was built with a systematic simulation toolset consisting of three consecutive parts: (1) building a global cross-linked PEGchain network at experimentally determined cross-link density using an on-lattice Monte Carlo method based on the bond fluctuation model, (2) recovering the local molecular structure of the network by transitioning from the lattice model to an off-lattice coarse-grained (CG) model parameterized from PCFF, followed by equilibration using high performance molecular dynamics methods, and (3) recovering the atomistic structure of the network by reverse mapping from the equilibrated CG structure, hydrating the structure with explicitly represented water, followed by final equilibration using PCFF parameterization. The developed three-stage modeling approach has application to a wide range of other complex macromolecular hydrogel systems, including the integration of peptide, protein, and/or drug molecules as side-chains within the hydrogel network for the incorporation of bioactivity for tissue engineering, regenerative medicine, and drug delivery applications.

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“…[9,16] Besides, surfaces exhibiting chemical contrasts represent a platform of choice for optimizing the biomolecule-surface interactions. [17][18][19] For instance, contrasted surfaces with bioadhesive and non-bioadhesive areas allow an accurate spatial control of protein adhesion. [20][21][22] Numerous methods for producing micro and nano-patterned surfaces have been developed.…”

Section: Introductionmentioning

confidence: 99%

Interactions of Serum Derived Proteins with Sub‐Micrometer Structured Surfaces

Perez-Roldan

Parracino

Ceccone

et al. 2014

Plasma Processes & Polymers

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This work presents the development and optimization of two fabrication methods that combine plasma polymerization and electron beam lithography techniques for producing chemical patterns at the sub-micro scale. The first method uses sacrificial resist as mask to produce the functionalization of the bioadhesive areas and the second method consists in the direct EBL writing of adhesive regions on a non-adhesive plasma deposited PEO-like film. The produced patterned surfaces exhibit high binding capacity as tested by Surface Plasmon Resonance Imaging with Human Serum Albumin. Furthermore, we show that adsorption on the structured surfaces is similar to that observed on a flat surface with a direct proportionality to the active area. This work shows the efficiency and suitability of the developed chemical patterning techniques and their high potential applicability for the study of protein surface interactions and miniaturized biosensing device development.

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Chemical patterning in biointerface science

Cited by 74 publications

References 152 publications

Fabrication of Arbitrary Three‐Dimensional Polymer Structures by Rational Control of the Spacing between Nanobrushes

Fabrication of Arbitrary Three‐Dimensional Polymer Structures by Rational Control of the Spacing between Nanobrushes

Multiscale approach for the construction of equilibrated all-atom models of a poly(ethylene glycol)-based hydrogel

Interactions of Serum Derived Proteins with Sub‐Micrometer Structured Surfaces

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