Chemical nature and biological effects of the aflatoxins

Wogan, G. N.

doi:10.1128/br.30.2.460-470.1966

Cited by 188 publications

(31 citation statements)

References 41 publications

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“…AFB! has an LD50 in the range of 0.5 to 10 mg/kg of body weight for most species tested (Wogan, 1966). The remaining chloroform-soluble metabolites have all been found to be considerably less toxic than AFBi.…”

Section: Resultsmentioning

confidence: 95%

Bovine liver metabolism and tissue distribution of aflatoxin B1

Hayes¹,

Polan²,

Campbell³

1977

J. Agric. Food Chem.

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Section: Resultsmentioning

confidence: 95%

Bovine liver metabolism and tissue distribution of aflatoxin B1

Hayes¹,

Polan²,

Campbell³

1977

J. Agric. Food Chem.

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“…2,3,3a,8a-Tetrahydrofuro[2,3- b ]benzofuran ( 1 ) is the parent compound of an important number of natural products with both toxic and therapeutic properties. − Thus, 1 is present in a metabolite denoted aflatoxin B 1 , which is produced by Aspergillus flavus and is able to contaminate different types of foods . On the other hand, 1 is also a constituent of semiglabrin 6 and microminutinin, which have been successfully applied in antimalarial therapies.…”

Section: Introductionmentioning

confidence: 99%

Conformational Preferences of 2,3,3a,8a-Tetrahydrofuro[2,3-b]benzofuran. The Chemical Modifications Drive the Pseudorotational Preferences

et al. 1999

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“…Mlatoksinler, depolanmış hemen her çeşit yem ve yem hammaddeleri ile besinlerde ve doğada yaygın bir şekilde bulunan toksijenik Aspergillis flavus ile çeşitli Aspergillus, Penicillium ve Rhizopus suşları tarafından sentezlenen toksik metabolitlerdir (17,20,24,53). Söz konusu küfler her zaman toksijenik değildir ama aerobik şartlarda ve ortam rutubet içeriğinin (% 15'den fazla), ısısının (20-30°C arasında, optimum 24°C) ve havalandırmanın uygun olduğu durumlarda depolanan yem ve tahıllarda hızla üreyip, toksin sentezleyebilirler (24,31,41).…”

Section: Introductionunclassified

KVFLENMEKTEN ŞÜPHELİ YEM VE YEM 'HAMMADDELERİxDE AFLATOKSİI\'LER

Şanlı¹

1985

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The pwpose of the study was to review the recent data a60ut aflatoxins and aflatoxicoses in animals and to analy<.e the residue leljel of aflatoxins in feeds and feedstuffs suspected with mouldy sent to the D~partment of Pharmacolog_y and Toaicology.Experiments were carried out totally in 76 feed and feedstufl samples comprising ten laying hen feeds, four laying chick growth feeds, sixteen broiler feeds, nine livestock feeds and one fishfeed and thirty-six a variety of feedstuff samples. Samples were analy<.ed by a thin-layer chromatographic procedure.The rale of incidenee of aflatoxins was determined to be B ı in 17 samples, B 2 in 2 samııles. None of the samples contained any detectable level of aflatoxin G ı and G 2 • The mean level of aflatoxin B ı was ealculated as 12.28 ppb and Bı as 8.5 ppb in the total samples. Aflatoxin Bı in the highest level wasfound in the broiler feeds (34.8 ppb), followed in the soya meal (20 ppb), the livestock feed (I 5,2 pp b) and the cottonseed meal (I 5 ppb). All of the meatstone meal, wheat, com, crushed shrimp and fish feed had no detectable resi-o dues of any aflatoxin. lt is concluded that the incidence and contamination level af aflatoxines ili feeds and feedstuffs has bem olJServedcomparatively less than those reported in the most literaturesand these suspected feeeds and feedstuffs may have. any other ha<.ardous substances such as other mauld toxins and possible pesticides.Özet: Bu çalışma kapsamında aflatoksinler ve evcilhayvanlarda aflatoksikodar hakkında son bilgüer incelenmiş ve kiiflenmekten şiipheyle rarma-

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Chemical nature and biological effects of the aflatoxins

Cited by 188 publications

References 41 publications

Bovine liver metabolism and tissue distribution of aflatoxin B1

Bovine liver metabolism and tissue distribution of aflatoxin B1

Conformational Preferences of 2,3,3a,8a-Tetrahydrofuro[2,3-b]benzofuran. The Chemical Modifications Drive the Pseudorotational Preferences

KVFLENMEKTEN ŞÜPHELİ YEM VE YEM 'HAMMADDELERİxDE AFLATOKSİI\'LER

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