Bovine liver metabolism and tissue distribution of aflatoxin B1

Hayes, Jeffrey A.; Polan, C.E.; Campbell, T. C.

doi:10.1021/jf60213a042

Cited by 19 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…AFB2 a (75) was discovered while testing the ability of various microbes to detoxify AFB1 [67]. AFM1 (76), isolated from AFB1 metabolites hydroxylated by the hepatic microsomal mixed-function oxidase system (MFO), mainly cytochromes, in the liver of mammals [68]. AFM2 (77) was isolated from A. parasiticus [69].…”

Section: Difurocoumarocyclopentenone Aflatoxinsmentioning

confidence: 99%

“…AFQ2 a (81), acid hydration of AFQ1 (80) [73]. Aflatoxicol M1 (82) was a reduced metabolite of AFB1, AFR0, or AFM1 catalysed by soluble NADPH-dependent reductases in the liver [68]. Aflatoxicol B1 (83) a metabolite of AFB1 (73) formed by a reversible reduction of the pentanone group in humans, animals and numerous bacteria and moulds [74].…”

Section: Difurocoumarocyclopentenone Aflatoxinsmentioning

confidence: 99%

See 1 more Smart Citation

The Biosynthesis, Structure Diversity and Bioactivity of Sterigmatocystins and Aflatoxins: A Review

Li,

Chen,

et al. 2024

JoF

View full text Add to dashboard Cite

Sterigmatocystins and aflatoxins are a group of mycotoxins mainly isolated from fungi of the genera Aspergillus. Since the discovery of sterigmatocystins in 1954 and aflatoxins in 1961, many scholars have conducted a series of studies on their structural identification, synthesis and biological activities. Studies have shown that sterigmatocystins and aflatoxins have a wide range of biological activities such as antitumour, antibacterial, anti-inflammatory, antiplasmodial, etc. The sterigmatocystins and aflatoxins had been shown to be hepatotoxic and nephrotoxic in animals. This review attempts to give a comprehensive summary of progress on the chemical structural features, synthesis, and bioactivity of sterigmatocystins and aflatoxins reported from 1954 to April 2024. A total of 72 sterigmatocystins and 20 aflatoxins are presented in this review. This paper reviews the chemical diversity and potential activity and toxicity of sterigmatocystins and aflatoxins, enhances the understanding of sterigmatocystins and aflatoxins that adversely affect humans and animals, and provides ideas for their prevention, research and development.

show abstract

Section: Difurocoumarocyclopentenone Aflatoxinsmentioning

confidence: 99%

Section: Difurocoumarocyclopentenone Aflatoxinsmentioning

confidence: 99%

The Biosynthesis, Structure Diversity and Bioactivity of Sterigmatocystins and Aflatoxins: A Review

Li,

Chen,

et al. 2024

JoF

View full text Add to dashboard Cite

show abstract

“…Assumed to be in edible parts of bovine fed on aflatoxin B1-contaminated feed [27,34,39] Aflatoxin Q2a Acid hydration of aflatoxin Q1 NA [40] Aflatoxicol (R0) Mainly vegetal products prone to contamination with A. flavus and A. parasiticus; not considered to be relevant to food products of animal origin [35,53] a Not a typical producer of G-types of aflatoxins, but some strains were reported to produce them in addition to B1 and B2 [11]; b Usually considered as a sperate mycotoxin produced by A. flavus because of structural differences with the difurocoumarin structure that characterizes the aflatoxins. Abbreviations: NA: Not available.…”

Section: ]mentioning

confidence: 99%

Aflatoxins: Production, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries

Benkerroum¹

2020

Preprint

View full text Add to dashboard Cite

This review aimed to update the main aspects of aflatoxin production, occurrence and incidence in selected countries, and associated aflatoxicosis outbreaks. Means to reduce aflatoxin incidence in crops were also presented with an emphasis on the environment-friendly technology using atoxigenic strains of Aspergillus flavus. Aflatoxins are unavoidable widespread natural contaminants of foods and feeds with serious impact on health, agricultural and livestock productivity, and food safety. They are secondary metabolites produced by Aspergillus species distributed on three main sections of the genus (section Flavi, section Ochraceorosei, and section Nidulantes). Poor economic status of a country exacerbates the risk and the extent of crop contamination due to faulty storage conditions that are usually suitable for mold growth and mycotoxin production: temperature of 22 to 29°C and water activity of 0.90 to 0.99. This situation paralleled the prevalence of high liver cancer and the occasional acute aflatoxicosis episodes that have been associated with these regions. Risk assessment studies revealed that Southeast Asian and Sub-Saharan African countries remain at high risk and that, apart from the regulatory standards revision to be more restrictive, other actions to prevent or decontaminate crops are to be taken for adequate public health protection. Indeed, a review of publications on the incidence of aflatoxins in selected foods and feeds from countries whose crops are classically known for their highest contamination with aflatoxins, reveals that despite the intensive efforts made to reduce such an incidence, there has been no clear tendency, with the possible exception of South Africa, towards sustained improvements. Nonetheless, a global risk assessment of the new situation regarding crop contamination with aflatoxins by international organizations with the required expertise is suggested to appraise where we stand presently.

show abstract

“…Moreover, mycotoxin residues in food of animal origin may pose a threat to humans through their carcinogenic, teratogenic, immunosuppressive and other adverse effects (Hussein & Brasel, 2001). Aflatoxins, especially aflatoxin B 1 , which can be found as a residue in animal liver and chicken eggs (Fernandes Oliveira et al, 2000;Hayes, Polan, & Campbell, 1977) are thought to be most potent mycotoxins. Their content in food and feed is regulated by legislation worldwide, also in EU (European Commission, 2001, 2002a, 2002bEuropean Parliament and Council, 2002;FAO, 2004).…”

Section: Introductionmentioning

confidence: 99%

Validation of the procedure for the determination of aflatoxin B1 in animal liver using immunoaffinity columns and liquid chromatography with postcolumn derivatisation and fluorescence detection

et al. 2007

View full text Add to dashboard Cite

Bovine liver metabolism and tissue distribution of aflatoxin B1

Cited by 19 publications

References 23 publications

The Biosynthesis, Structure Diversity and Bioactivity of Sterigmatocystins and Aflatoxins: A Review

The Biosynthesis, Structure Diversity and Bioactivity of Sterigmatocystins and Aflatoxins: A Review

Aflatoxins: Production, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries

Validation of the procedure for the determination of aflatoxin B1 in animal liver using immunoaffinity columns and liquid chromatography with postcolumn derivatisation and fluorescence detection

Contact Info

Product

Resources

About