Chemical modifiers

Bartelink, H.; Bleehen, N.M.; Phillips, T.L.

doi:10.1016/0360-3016(88)90165-4

Cited by 5 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Method 3. A vial of dried NaTc04 was prepared as in method 1 with the exception that the stir bar was not added. The vial was placed in a commercially available ultrasonic bath (Bransonic 2200) and irradiated for 60 min.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization and myocardial uptake of cationic bis(arene)technetium(I) complexes

Wester¹,

Coveney²,

Nosco³

et al. 1991

J. Med. Chem.

View full text Add to dashboard Cite

A series of bis(arene)technetium(I) complexes has been synthesized from 99mTcO4- in order to study their organ distribution. Syntheses using either ultrasound/Al/AlCl3 or Zn/HCl gave products relatively free from transalkylation. The identity of the complexes was verified by comparison to the 99Tc complexes. Equivalence of the 99Tc and 99mTc complexes was demonstrated by HPLC techniques. Biodistribution studies in rats reveal substantial myocardial uptake for many members of the series, especially those containing benzene rings substituted with about four to six carbon atoms. The myocardial uptake is related to the lipophilicity of the complexes as measured by octanol/buffer partition ratios (OBPR). Optimal ranges of lipophilicity for maximal myocardial uptake occur for OBPR from 2 to 9. Rat and human plasma binding of the complexes increases with lipophilicity after a threshold value is exceeded.

show abstract

Section: Methodsmentioning

confidence: 99%

“…A variety of nitroheterocycles and quiñones have been shown to sensitize cells to radiation in vitro by this mechanism. However, to date, only nitroimidazoles have displayed in vivo activity sufficient to conduct clinical trials.1"3 One of the most widely studied nitroimidazoles has been misonidazole (1). Although effective as a raf >-NO* I CH2CHCH2OMe…”

mentioning

confidence: 99%

Synthesis, characterization and myocardial uptake of cationic bis(arene)technetium(I) complexes

Wester¹,

Coveney²,

Nosco³

et al. 1991

J. Med. Chem.

View full text Add to dashboard Cite

show abstract

“…Misonidazole is, however, unlikely to achieve optimal radiosensitization in man as a result of its dose-limiting neurotoxicity (e.g. Wasserman et al, 1979;Dische et al, 1982), and less neurotoxic and/or more potent analogues are undergoing development (Bartelink et al, 1988).…”

mentioning

confidence: 99%