Chemical Methods of Oligonucleotide Synthesis

Studies on the Stereo‐ and Enantioselective Synthesis of 11,12‐epoxy‐Sarcophytol‐A, 11,12‐epoxysarcophytol‐A acetate and 11,12‐epoxy‐cembrene‐C. Synthesis of 5,9,13‐trimethyl‐2‐isopropyl‐12(S),12(S)‐epoxy‐14‐bromo‐2(Z),4(E),8(E)‐tetradecatrienenitrile

“…74ml, 2. 5mmol ) , C a H z ( 15mg ) , 4 A molecular sieves ( 40mg ) and silica gel ( 20mg ) in dry CHzCl2 (25ml) was injected L ( 4-) DET ( 0. 51ml, 3mmol) Via syringe under Ar at -20°C.…”

Rate Enhancements in the Acetylation and Benzoylation of Certain Aromatic Compounds with Vilsmeier-Haack Reagents Using Acetamide, Benzamide and Oxychlorides under Non-Conventional Conditions

“…The most commonly used reagent combination for this reaction uses acid anhydride in the presence of acid or base catalysts [3]. Various metal salts [4][5][6][7][8][9][10][11][12][13][14][15][16] such as CoCl 2 , TiCl 4 -AgClO 4 , TaCl 5 , TaCl 5 -SiO 2 , Ce(III) triflate, Sn(IV) porphyrine and some metal triflates [17][18][19][20][21] such as Sc (OTf) 3 , MeSiOTf, In(OTf) 3 , Cu(OTf) 2 and Bi(OTf) 3 , bis(cyclopentadienyl) zirconium dichloride [22], I 2 [23], 1,3-dibromo-5,5-dimethylhydentoin or trichloroisocyanuric acid [24] have been investigated to meet the demand for more efficient and selective methods.…”

Zinc dust: An extremely active and reusable catalyst in acylation of phenols, thiophenol, amines and alcohols in a solvent-free system

“…Acylation of such functional groups is often necessary during the course of various transformations in a synthetic sequence, especially in the construction of polyfunctional molecules such as peptides, nucleosides, oligonucleotides, carbohydrates, steroids and other natural products [1][2][3]. Various catalysts developed for acylation with acyl halides include use of bases like pyridine and Et3N [4][5], DMAP [6], and Bu3P [7]. Acylation with acids [8,9], acyl imidazoles [10], and acyl urea [11], are also known.…”