Chemical investigation and screening of anti-cancer potential of Syzygium aromaticum L. bud (clove) essential oil nanoemulsion

Abadi, Atena Vafaei Malek; Karimi, Ehsan; Oskoueian, Ehsan; Mohammad, Ghasem Rahimi Kalateh Shah; Shafaei, Negin

doi:10.1007/s13205-022-03117-2

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…The powerful antioxidant, antiproliferative, and antibacterial effects of Syzygium aromaticum (clove) are attributed to its tannins, flavonol glycosides, and volatile phenolic oils (eugenol, acetyl eugenol). It is perfect for use as a cancer chemo preventive drug since it has qualities that make it antibacterial, antiseptic, and anti-inflammatory [ 50 ]. Eugenol may have an apoptotic effect by reducing cyclooxygenase-2 (COX-2), B-cell lymphoma, and interleukin-1 beta production, and by increasing the activity of caspase-3 and caspase-9 caspase proteins.…”

Section: Resultsmentioning

confidence: 99%

Anticancer of genus Syzygium: a systematic review

Abdulrahman

Hama

2023

Exploration of Targeted Anti-Tumor Therapy

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Aim: One in eight fatalities globally are considered cancer-related. The need for cancer therapy is growing. Natural products continue to play a role in drug development, as up to 50% of authorized drugs in the last 30 years have been isolated from natural sources. Methods: Anticancer, antioxidant, antibacterial, antifungal, antiviral, analgesic, anti-inflammatory, and other actions have all been reported in research papers using plants from the Syzygium genus in the treatment and prevention of disease. Results: Results from the anticancer test showed that the genus, especially Syzygium aqueum, Syzygium samarangense, and Syzygium cumini had significant promise as an anticancer agent in vitro against several cancer cell lines. Numerous factors, including phytochemical composition, increased apoptotic activity, decreased cell proliferation, stopped angiogenesis, and reduced inflammation. Conclusions: These results, despite preliminary, show promise for further purification and investigation of bioactive compounds and extracts within the genus Syzygium for their anticancer properties.

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Section: Resultsmentioning

confidence: 99%

Anticancer of genus Syzygium: a systematic review

Abdulrahman

Hama

2023

Exploration of Targeted Anti-Tumor Therapy

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“…Due to essential oils' degradability and volatile nature in order to optimize their pharmaceutical performance and stability multiple drug delivery systems have been improvised. Nano emulsification of phytochemicals by natural compounds is a novel and safe drug delivery approach to cancer cells ( Navaei Shoorvarzi et al, 2020 ; Abadi et al, 2022 ). In this study, we produced solid spherical nanoemulsions containing ZEO ranging from 100–184 nm via the non-covalent interactions between AP and ZEO.…”

Section: Discussionmentioning

confidence: 99%

Apple pectin-based Zataria multiflora essential oil (ZEO) nanoemulsion: An approach to enhance ZEO DNA damage induction in breast cancer cells as in vitro and in silico studies reveal

et al. 2022

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Zataria multiflora essential oil (ZEO) is a natural complex of compounds with a high apoptotic potential against breast cancer cells and minor toxicity toward normal cells; however, similar to many essential oils, ZEO utilization in pharmaceutical industries has limitations due to its labile and sensitive ingredients. Nanoemulsification based on natural polymers is one approach to overcome this issue. In this study, an apple pectin-ZEO nanoemulsion (AP-ZEONE) was prepared and its morphology, FTIR spectra, and physical properties were characterized. Furthermore, it was shown that AP-ZEONE substantially suppresses the viability of MDA-MB-231, T47D, and MCF-7 breast cancer cells. AP-ZEONE significantly induced apoptotic morphological alterations and DNA fragmentation as confirmed by fluorescent staining and TUNEL assay. Moreover, AP-ZEONE induced apoptosis in MDA-MB-231 cells by loss of mitochondrial membrane potential (ΔΨm) associated with the accumulation of reactive oxygen species (ROS), G2/M cell cycle arrest, and DNA strand breakage as flow cytometry, DNA oxidation, and comet assay analysis revealed, respectively. Spectroscopic and computational studies also confirmed that AP-ZEONE interacts with genomic DNA in a minor groove/partial intercalation binding mode. This study demonstrated the successful inhibitory effect of AP-ZEONE on metastatic breast cancer cells, which may be beneficial in the therapy process.

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“…More recently, to improve the medicinal properties of Syzygium aromaticum L., S. aromaticum L. bud EO was nanoformulated using the ultrasonication NE technique to obtain nanosized DSs (SABE-NE) with 131 nm sized particles [ 188 ]. While the produced SABE-NE induced an apoptotic response and significant cell death in HT-29 cancer cells, normal HFF cells exerted limited cytotoxic impacts.…”

Section: Nanotechnologymentioning

confidence: 99%

“…While the produced SABE-NE induced an apoptotic response and significant cell death in HT-29 cancer cells, normal HFF cells exerted limited cytotoxic impacts. Moreover, in vivo tests on mouse livers demonstrated the cytoprotective properties of SABE-NE [ 188 ].…”

Section: Nanotechnologymentioning

confidence: 99%

Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

Zuccari

Alfei

2023

IJMS

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The awareness of the existence of plant bioactive compounds, namely, phytochemicals (PHYs), with health properties is progressively expanding. Therefore, their massive introduction in the normal diet and in food supplements and their use as natural therapeutics to treat several diseases are increasingly emphasized by several sectors. In particular, most PHYs possessing antifungal, antiviral, anti-inflammatory, antibacterial, antiulcer, anti-cholesterol, hypoglycemic, immunomodulatory, and antioxidant properties have been isolated from plants. Additionally, their secondary modification with new functionalities to further improve their intrinsic beneficial effects has been extensively investigated. Unfortunately, although the idea of exploiting PHYs as therapeutics is amazing, its realization is far from simple, and the possibility of employing them as efficient clinically administrable drugs is almost utopic. Most PHYs are insoluble in water, and, especially when introduced orally, they hardly manage to pass through physiological barriers and scarcely reach the site of action in therapeutic concentrations. Their degradation by enzymatic and microbial digestion, as well as their rapid metabolism and excretion, strongly limits their in vivo activity. To overcome these drawbacks, several nanotechnological approaches have been used, and many nanosized PHY-loaded delivery systems have been developed. This paper, by reporting various case studies, reviews the foremost nanosuspension- and nanoemulsion-based techniques developed for formulating the most relevant PHYs into more bioavailable nanoparticles (NPs) that are suitable or promising for clinical application, mainly by oral administration. In addition, the acute and chronic toxic effects due to exposure to NPs reported so far, the possible nanotoxicity that could result from their massive employment, and ongoing actions to improve knowledge in this field are discussed. The state of the art concerning the actual clinical application of both PHYs and the nanotechnologically engineered PHYs is also reviewed.

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Chemical investigation and screening of anti-cancer potential of Syzygium aromaticum L. bud (clove) essential oil nanoemulsion

Cited by 15 publications

References 30 publications

Anticancer of genus Syzygium: a systematic review

Anticancer of genus Syzygium: a systematic review

Apple pectin-based Zataria multiflora essential oil (ZEO) nanoemulsion: An approach to enhance ZEO DNA damage induction in breast cancer cells as in vitro and in silico studies reveal

Development of Phytochemical Delivery Systems by Nano-Suspension and Nano-Emulsion Techniques

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